Sex differences in fear memory consolidation via Tac2 signaling in mice

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  • dc.contributor.author Florido Torres, Antonio Luis
  • dc.contributor.author Velasco, Eric R.
  • dc.contributor.author Soto-Faguás, Carlos M.
  • dc.contributor.author Gómez-Gómez, Àlex
  • dc.contributor.author Pérez-Caballero, Laura
  • dc.contributor.author Molina, Patricia
  • dc.contributor.author Nadal, Roser
  • dc.contributor.author Pozo Mendoza, Óscar J., 1975-
  • dc.contributor.author Saura, Carlos A.
  • dc.contributor.author Andero, Raül
  • dc.date.accessioned 2021-10-26T05:58:18Z
  • dc.date.available 2021-10-26T05:58:18Z
  • dc.date.issued 2021
  • dc.description.abstract Memory formation is key for brain functioning. Uncovering the memory mechanisms is helping us to better understand neural processes in health and disease. Moreover, more specific treatments for fear-related disorders such as posttraumatic stress disorder and phobias may help to decrease their negative impact on mental health. In this line, the Tachykinin 2 (Tac2) pathway in the central amygdala (CeA) has been shown to be sufficient and necessary for the modulation of fear memory consolidation. CeA-Tac2 antagonism and its pharmacogenetic temporal inhibition impair fear memory in male mice. Surprisingly, we demonstrate here the opposite effect of Tac2 blockade on enhancing fear memory consolidation in females. Furthermore, we show that CeA-testosterone in males, CeA-estradiol in females and Akt/GSK3β/β-Catenin signaling both mediate the opposite-sex differential Tac2 pathway regulation of fear memory.
  • dc.description.sponsorship We would also like to thank Noemí Haro for help with estradiol determination. Procedural images were created with BioRender.com. RA was supported by a NARSAD Young Investigator Grant #22434, Ramón y Cajal program RYC2014-15784, RETOS-MICINN SAF2016-76565-R FEDER funds, and ERANET-Neuron JTC 2019 ISCIII AC19/00077. CAS is supported by Ministerio de Ciencia e Inovación (MICINN) grant SAF2016-80027-R, PID2019-106615RB-100, and ISCIII (CIBERNED CB06/05/0042). RN was supported by MICINNgrant SAF2017-83430 and was a recipient of an ICREA Academia Award (Generalitat de Catalunya, 2015-2019). AF 2018 FI_B00030 and CMS 2017 FI_B00326 were recipients of Generalitat de Catalunya predoctoral fellowship. ERV was supported by BES-2017-080870 FPI-2017 fellowship from MINECO. LPC was supported by an FJC2018-037958-I (MCIyU). PM received support from FPU16/05416 (MCECD). OP was supported by the Spanish Health National System CPII16/00027.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Florido A, Velasco ER, Soto-Faguás CM, Gomez-Gomez A, Perez-Caballero L, Molina P, Nadal R, Pozo OJ, Saura CA, Andero R. Sex differences in fear memory consolidation via Tac2 signaling in mice. Nat Commun. 2021;12(1):2496. DOI: 10.1038/s41467-021-22911-9
  • dc.identifier.doi http://dx.doi.org/10.1038/s41467-021-22911-9
  • dc.identifier.issn 2041-1723
  • dc.identifier.uri http://hdl.handle.net/10230/48808
  • dc.language.iso eng
  • dc.publisher Nature Research
  • dc.relation.ispartof Nat Commun. 2021;12(1):2496
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2016-76565-R
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2016-80027-R
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/SAF2017-83430
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BES-2017-080870
  • dc.rights © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Amygdala
  • dc.subject.keyword Classical conditioning
  • dc.subject.keyword Fear conditioning
  • dc.subject.keyword Preclinical research
  • dc.title Sex differences in fear memory consolidation via Tac2 signaling in mice
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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