Thalamocortical spectral transmission relies on balanced input strengths

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• dc.contributor.author Saponati, Matteo
• dc.contributor.author García Ojalvo, Jordi
• dc.contributor.author Cataldo, Enrico
• dc.contributor.author Mazzoni, Alberto
• dc.date.accessioned 2021-07-19T06:09:08Z
• dc.date.available 2021-07-19T06:09:08Z
• dc.date.issued 2022
• dc.description.abstract The thalamus is a key element of sensory transmission in the brain, as it gates and selects sensory streams through a modulation of its internal activity. A preponderant role in these functions is played by its internal activity in the alpha range ([8-14] Hz), but the mechanism underlying this process is not completely understood. In particular, how do thalamocortical connections convey stimulus driven information selectively over the back-ground of thalamic internally generated activity? Here we investigate this issue with a spiking network model of feedforward connectivity between thalamus and primary sensory cortex reproducing the local field potential of both areas. We found that in a feedforward network, thalamic oscillations in the alpha range do not entrain cortical activity for two reasons: (i) alpha range oscillations are weaker in neurons projecting to the cortex, (ii) the gamma resonance dynamics of cortical networks hampers oscillations over the 10-20 Hz range thus weakening alpha range oscillations. This latter mechanism depends on the balance of the strength of thalamocortical connections toward excitatory and inhibitory neurons in the cortex. Our results highlight the relevance of corticothalamic feedback to sustain alpha range oscillations and pave the way toward an integrated understanding of the sensory streams traveling between the periphery and the cortex.
• dc.description.sponsorship J.G.O. was supported by the Spanish Ministry of Science, Innovation and Universities and FEDER (Project PGC2018-101251-B-I00 and Maria de Maeztu Programme, project CEX2018-000792-M ), the Generalitat de Catalunya (Project 2017 SGR 1054), and the ICREA Academia programme. E.C. was supported by the grant “PANACEE” (Prevision and analysis of brain activity in transitions: epilepsy and sleep) of the Regione Toscana – PAR FAS 2007–2013 1.1.a.1.1.2 – B22I14000770002. AM was supported by the Italian Ministry of Research (MIUR, PRIN2017, PROTECTION, Project 20178L7WRS).
• dc.format.mimetype application/pdf
• dc.identifier.citation Saponati M, Garcia-Ojalvo J, Cataldo E, Mazzoni A. Thalamocortical spectral transmission relies on balanced input strengths. Brain Topogr. 2022 Jan;35(1):4-18. DOI: 10.1007/s10548-021-00851-3
• dc.identifier.doi http://dx.doi.org/10.1007/s10548-021-00851-3
• dc.identifier.issn 0896-0267
• dc.identifier.uri http://hdl.handle.net/10230/48216
• dc.language.iso eng
• dc.publisher Springer
• dc.relation.ispartof Brain Topogr. 2022 Jan;35(1):4-1
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-101251-B-I00
• dc.rights © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Collective dynamics
• dc.subject.keyword Information transmission
• dc.subject.keyword Neural networks
• dc.subject.keyword Parametrical analysis
• dc.subject.keyword Thalamocortical system
• dc.title Thalamocortical spectral transmission relies on balanced input strengths
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion