Impact of phenol-enriched virgin olive oils on the postprandial levels of circulating microRNAs related to cardiovascular disease

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• dc.contributor.author Daimiel, Lidia
• dc.contributor.author Micó, Víctor
• dc.contributor.author Valls, Rosa M.
• dc.contributor.author Pedret, Anna
• dc.contributor.author Motilva, Maria-José
• dc.contributor.author Rubió, Laura
• dc.contributor.author Fitó Colomer, Montserrat
• dc.contributor.author Farràs Mañé, Marta
• dc.contributor.author Covas Planells, Maria Isabel
• dc.contributor.author Solá, Rosa
• dc.contributor.author Ordovás, José M.
• dc.date.accessioned 2021-10-05T05:54:35Z
• dc.date.available 2021-10-05T05:54:35Z
• dc.date.issued 2020
• dc.description.abstract Scope: We investigate the postprandial modulation of cardiovascular-related microRNAs elicited by extra virgin olive oil (EVOOs) containing different levels of their own polyphenols. Methods and results: It is randomized, postprandial, parallel, double-blind study. Twelve healthy participants consumed 30 mL of EVOO containing low (L-EVOO; 250 mg total phenols kg-1 of oil), medium (M-EVOO; 500 mg total phenols kg-1 of oil), and high (H-EVOO; 750 mg total phenols kg-1 of oil) enriched EVOOs. Postprandial plasma microRNAs levels are analyzed by real-time quantitative PCR. The results show that L-EVOO intake is associated with decreased let-7e-5p and miR-328a-3p levels and increased miR-17-5p and miR-20a-5p, concentrations. M-EVOO decreases plasma let-7e-5p and increases miR-17-5p, miR-20a-5p, and miR-192-5p levels. Finally, H-EVOO decreases let-7e-5p, miR-10a-5p, miR-21-5p, and miR-26b-5p levels. Conclusion: During the postprandial state, the levels of let-7e-5p decrease with EVOO regardless of polyphenol content suggesting a general response to the fatty acid composition of EVOO or/and the presence of at least 250 mg polyphenol kg-1 olive oil. Moreover, the miR-17-92 cluster increases by low and medium polyphenol content suggesting a role in fatty acid metabolism and nutrient sensing. Thus, postprandial modulation of circulating microRNAs levels could be a potential mechanism for the cardiovascular benefits associated with EVOO intake.
• dc.format.mimetype application/pdf
• dc.identifier.citation Daimiel L, Micó V, Valls RM, Pedret A, Motilva MJ, Rubió L, Fitó M, Farrás M, Covas MI, Solá R, Ordovás JM. Impact of phenol-enriched virgin olive oils on the postprandial levels of circulating microRNAs related to cardiovascular disease. Mol Nutr Food Res. 2020;64(15):e2000049. DOI: 10.1002/mnfr.202000049
• dc.identifier.doi http://dx.doi.org/10.1002/mnfr.202000049
• dc.identifier.issn 1613-4125
• dc.identifier.uri http://hdl.handle.net/10230/48558
• dc.language.iso eng
• dc.publisher Wiley-VCH Verlag
• dc.relation.ispartof Mol Nutr Food Res. 2020;64(15):e2000049
• dc.rights © 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Biomarkers
• dc.subject.keyword Cardiovascular disease
• dc.subject.keyword Extra virgin olive oil
• dc.subject.keyword Mediterranean diet
• dc.subject.keyword microRNAs
• dc.title Impact of phenol-enriched virgin olive oils on the postprandial levels of circulating microRNAs related to cardiovascular disease
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion