Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis: Differences between males and females

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  • dc.contributor.author Serra-Navarro, Maria
  • dc.contributor.author Amoretti, Silvia
  • dc.contributor.author Verdolini, Norma
  • dc.contributor.author Forte, María Florencia
  • dc.contributor.author Sánchez-Torres, Ana M.
  • dc.contributor.author Vieta, Eduard
  • dc.contributor.author Clougher, Derek
  • dc.contributor.author Lobo, Antonio
  • dc.contributor.author González-Pinto, Ana
  • dc.contributor.author Panadero, Rocío
  • dc.contributor.author Roldán, Alexandra
  • dc.contributor.author Carvalho, André F.
  • dc.contributor.author Serna, Elena de la
  • dc.contributor.author Toll Privat, Alba
  • dc.contributor.author Ramos Quiroga, Josep Antoni
  • dc.contributor.author Torrent, Carla
  • dc.contributor.author Cuesta, Manuel J.
  • dc.contributor.author Bernardo, Miquel
  • dc.contributor.author PEPs Group
  • dc.date.accessioned 2023-04-05T06:15:59Z
  • dc.date.available 2023-04-05T06:15:59Z
  • dc.date.issued 2022
  • dc.description.abstract Background: Deficits in psychosocial functioning are present in the early stages of psychosis. Several factors, such as premorbid adjustment, neurocognitive performance, and cognitive reserve (CR), potentially influence functionality. Sex differences are observed in individuals with psychosis in multiple domains. Nonetheless, few studies have explored the predictive factors of poor functioning according to sex in first-episode psychosis (FEP). This study aimed to explore sex differences, examine changes, and identify predictors of functioning according to sex after onset. Materials and methods: The initial sample comprised 588 individuals. However, only adults with non-affective FEP (n = 247, 161 males and 86 females) and healthy controls (n = 224, 142 males and 82 females) were included. A comprehensive assessment including functional, neuropsychological, and clinical scales was performed at baseline and at 2-year follow-up. A linear regression model was used to determine the predictors of functioning at 2-year follow-up. Results: FEP improved their functionality at follow-up (67.4% of both males and females). In males, longer duration of untreated psychosis (β = 0.328, p = 0.003) and worse premorbid adjustment (β = 0.256, p = 0.023) were associated with impaired functioning at 2-year follow-up, while in females processing speed (β = 0.403, p = 0.003), executive function (β = 0.299, p = 0.020) and CR (β = -0.307, p = 0.012) were significantly associated with functioning. Conclusion: Our data indicate that predictors of functioning at 2-year follow-up in the FEP group differ according to sex. Therefore, treatment and preventative efforts may be adjusted taking sex into account. Males may benefit from functional remediation at early stages. Conversely, in females, early interventions centered on CR enhancement and cognitive rehabilitation may be recommended.
  • dc.description.sponsorship We are extremely grateful to all participants. This study is part of a coordinated-multicentre Project, funded by the Ministerio de Economía y Competitividad (PI08/0208; PI11/00325; PI17/01066; PI20/00344; and PI14/00612), Instituto de Salud Carlos III – Fondo Europeo de Desarrollo Regional, Unión Europea, Una manera de hacer Europa, Centro de Investigación Biomédica en Red de salud Mental, CIBERSAM, by the CERCA Programme/Generalitat de Catalunya and Secretaria d’Universitats i Recerca del Departament d’Economia I Coneixement (2017SGR1355). Departament de Salut de la Generalitat de Catalunya, en la convocatoria corresponent a l’any 2017 de Concessió de Subvencions del Pla Estratègic de Recerca i Innovació en Salut (PERIS) 2016–2020, Modalitat Projectes de Recerca Orientats A l’Atenció Primària, Amb el Codi d’Expedient SLT006/17/00345. MB is also grateful for the support of the Institut de Neurociències, Universitat de Barcelona. SA has been supported by a Sara Borrell (CD20/00177), funded by Instituto de Salud Carlos III (ISCIII), and co-funded by European Social Fund “Investing in your future”. NV thanks the BITRECS project, which has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 754550 and from “La Caixa” Foundation (ID 100010434), under the agreement LCF/PR/GN18/50310006. CT has been supported by a ‘Miguel Servet’ postdoctoral contract (CPI14/00175), and Miguel Servet II contract (CPII19/00018). EV thanks the support of the Spanish Ministry of Science, Innovation and Universities (PI15/00283; PI21/00787) integrated into the Plan Nacional de I + D + I y cofinanciado por el ISCIII-Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER); CIBERSAM; and the Comissionat per a Universitats i Recerca del DIUE de la Generalitat de Catalunya to the Bipolar Disorders Group (2017 SGR 1365) and the SLT006/17/00357 project, from PERIS 2016-2020 (Departament de Salut). CERCA Programme/Generalitat de Catalunya. A. Ibáñez thanks the support of the Madrid Regional Government and European Union Structural Funds (S2017/BMD3740; AGES-CM 2-CM), and the support of CIBERSAM. We also would like to thank the authors of the PEPs group who participated in the development of this manuscript.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Serra-Navarro M, Amoretti S, Verdolini N, Forte MF, Sánchez-Torres AM, Vieta E, Clougher D, Lobo A, González-Pinto A, Panadero R, Roldán A, Carvalho AF, de la Serna E, Toll A, Ramos-Quiroga JA, Torrent C, Cuesta MJ, Bernardo M; PEPs Group. Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis: Differences between males and females. Front Psychiatry. 2022 Oct 20;13:982583. DOI: 10.3389/fpsyt.2022.982583
  • dc.identifier.doi http://dx.doi.org/10.3389/fpsyt.2022.982583
  • dc.identifier.issn 1664-0640
  • dc.identifier.uri http://hdl.handle.net/10230/56412
  • dc.language.iso eng
  • dc.publisher Frontiers
  • dc.relation.ispartof Front Psychiatry. 2022 Oct 20;13:982583
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/754550
  • dc.rights © 2022 Serra-Navarro, Amoretti, Verdolini, Forte, Sánchez-Torres, Vieta, Clougher, Lobo, González-Pinto, Panadero, Roldán, Carvalho, de la Serna, Toll, Ramos-Quiroga, Torrent, Cuesta, Bernardo and PEPs Group. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Cognition
  • dc.subject.keyword First episode non-affective psychosis
  • dc.subject.keyword Negative symptoms
  • dc.subject.keyword Psychosocial functioning
  • dc.subject.keyword Sex differences
  • dc.title Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis: Differences between males and females
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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