Genetically modified mice as tools to understand the neurobiological substrates of depression
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- dc.contributor.author Robledo, Patricia, 1958-ca
- dc.contributor.author Martín García, Elena, 1975-ca
- dc.contributor.author Aso Pérez, Esterca
- dc.contributor.author Maldonado, Rafael, 1961-ca
- dc.date.accessioned 2016-01-22T07:54:55Z
- dc.date.available 2016-01-22T07:54:55Z
- dc.date.issued 2014ca
- dc.description.abstract The pathophysiological mechanisms underlying depression are still poorly understood. An initial hypothesis postulated to explain the substrates of depression was based on the involvement of monoaminergic systems. This early theory was proposed from different findings obtained using pharmacological tools and can explain the mechanism of action of the drugs currently used to treat depression. However, more recent studies have revealed that other neurobiological processes different from monoamines also participate in the substrates of depression. These mechanisms include the participation of several neuromodulatory systems, stress-related circuits and neuroplastic changes that could represent a direct substrate for these pathophysiological processes. The lack of selective pharmacological tools for several of these potential targets of depression represents an important limitation to study their potential involvement. In the last two decades, different lines of genetically modified mice have been generated with selective deletions in specific genes related to the control of emotional responses. This review summarizes the main findings that have been obtained with these novel genetic tools to clarify the neurobiological substrates of depression. A particular focus has been devoted to the advances obtained with mice deficient in specific components of the monoaminergic, opioid and cannabinoid system and those with mutations in elements of the hypothalamic-pituitary-adrenal axis.
- dc.description.sponsorship This work was supported by the Spanish “Ministerio de Ciencia e Innovación” (#SAF2007-64062 and SAF2011-29864), “Instituto de Salud Carlos III” (RETICS-Red de Trastornos Adictivos-Redes Temáticas de Investigación Cooperativa en Salud: #RD06/0001/0001, #RD06/0001/1004), grants #10/00316 and #10/01708 to PR. Plan Nacional sobre Drogas (PNSD #2009/026), the Marató of TV3, the Catalan Government (SGR2009-00131) and the ICREA Foundation (ICREA Academia-2008)
- dc.format.mimetype application/pdfca
- dc.identifier.citation Robledo P, Martín-García E, Aso E, Maldonado R. Genetically modified mice as tools to understand the neurobiological substrates of depression. Curr Pharm Des. 2014;20(23):3718-37. DOI: 10.2174/13816128113196660741ca
- dc.identifier.doi http://dx.doi.org/10.2174/13816128113196660741
- dc.identifier.issn 1381-6128ca
- dc.identifier.uri http://hdl.handle.net/10230/25634
- dc.language.iso engca
- dc.publisher Bentham Science Publishersca
- dc.relation.ispartof Current Pharmaceutical Design. 2014;20(23):3718-37
- dc.rights © Bentham Science Publishers. Article published in Robledo P, Martín-García E, Aso E, Maldonado R, Current pharmaceutical design. 23, 2014. The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Depressió psíquica -- Aspectes genètics
- dc.subject.other Depressió psíquica -- Etiologia
- dc.subject.other Malalties -- Models animals
- dc.subject.other Rates (Animals de laboratori)
- dc.title Genetically modified mice as tools to understand the neurobiological substrates of depressionca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca