Phase angle as surrogate marker of muscle weakness in kidney transplant candidates referred to prehabilitation

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• dc.contributor.author Marco Navarro, Ester
• dc.contributor.author Pérez-Sáez, María José
• dc.contributor.author Muñoz Redondo, Elena
• dc.contributor.author Curbelo Peña, Yulibeth
• dc.contributor.author Ramírez-Fuentes, Cindry
• dc.contributor.author Meza Valderrama, Delky
• dc.contributor.author Acuña-Pardo, Carolina
• dc.contributor.author Muns, Maria Dolors
• dc.contributor.author Vázquez Ibar, Olga
• dc.contributor.author Chamoun, Betty Odette
• dc.contributor.author Faura, Anna
• dc.contributor.author Bach Pascual, Anna
• dc.contributor.author Crespo Barrio, Marta
• dc.contributor.author Pascual Santos, Julio
• dc.contributor.author FRAILMar Study Group
• dc.date.accessioned 2025-07-11T07:00:43Z
• dc.date.available 2025-07-11T07:00:43Z
• dc.date.issued 2024
• dc.description.abstract Phase angle (PhA), a marker of nutritional status obtained by bioelectrical impedance analysis (BIA), is associated with the integrity of cell membranes. Damage to muscle fiber membranes can impact muscle strength, which is related to adverse outcomes in adults with advanced chronic kidney disease (CKD). The main objective of this study was to determine the usefulness of the PhA in identifying muscle weakness in candidates for kidney transplants (KTs). Secondly, it aimed to examine the associations of PhA with other parameters of body composition, exercise performance, and muscle structure. Sensitivity, specificity, and area under the receiver operating characteristics curve were used to evaluate the PhA (index test) as a biomarker of muscle weakness. Muscle strength was estimated with maximal voluntary isometric contraction of the quadriceps (MVCI-Q) of the dominant side. Muscle weakness was defined as MVIC-Q < 40% of body weight. A total of 119 patients were evaluated (mean age 63.7 years, 75.6% men). A phase angle cut-off of 5.1° was identified to classify men with a higher likelihood of having low muscle strength in upper limbs (MVIC-Q 40% of their body weight). Male KT candidates with PhA < 5.1° had poorer exercise capacity, lower muscle strength, less muscle mass, and smaller muscle size. A PhA < 5.1° was significantly associated with an eight-fold higher muscle weakness risk (OR = 8.2, 95%CI 2.3-29.2) in a binary regression model adjusted by age, frailty, and hydration status. Remarkably, PhA is an easily obtainable objective parameter in CKD patients, requiring no volitional effort from the individual. The associations of PhA with aerobic capacity, physical activity, muscle mass, and muscle size underscore its clinical relevance and potential utility in the comprehensive evaluation of these patients.
• dc.format.mimetype application/pdf
• dc.identifier.citation Marco E, Pérez-Sáez MJ, Muñoz-Redondo E, Curbelo YG, Ramírez-Fuentes C, Meza-Valderrama D, et al. Phase angle as surrogate marker of muscle weakness in kidney transplant candidates referred to prehabilitation. Nutrients. 2024 Jul 12;16(14):2245. DOI: 10.3390/nu16142245
• dc.identifier.doi http://dx.doi.org/10.3390/nu16142245
• dc.identifier.issn 2072-6643
• dc.identifier.uri http://hdl.handle.net/10230/70888
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Nutrients. 2024 Jul 12;16(14):2245
• dc.rights © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Advanced chronic kidney disease
• dc.subject.keyword Diagnostic accuracy
• dc.subject.keyword Kidney transplant
• dc.subject.keyword Muscle weakness
• dc.subject.keyword Phase angle
• dc.subject.keyword Prehabilitation
• dc.title Phase angle as surrogate marker of muscle weakness in kidney transplant candidates referred to prehabilitation
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion