Discrepancies in Composition and Biological Effects of Different Formulations of Chondroitin Sulfate

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• dc.contributor.author Martel-Pelletier, Johanneca
• dc.contributor.author Farran Díaz Cano, Ainaca
• dc.contributor.author Montell, Eulàliaca
• dc.contributor.author Vergés, Josepca
• dc.contributor.author Pelletier, Jean-Pierreca
• dc.date.accessioned 2015-04-08T10:48:09Z
• dc.date.available 2015-04-08T10:48:09Z
• dc.date.issued 2015
• dc.description.abstract Osteoarthritis is a common, progressive joint disease, and treatments generally aim for symptomatic improvement. However, SYmptomatic Slow-Acting Drugs in Osteoarthritis (SYSADOAs) not only reduce joint pain, but slow structural disease progression. One such agent is chondroitin sulfate-a complex, heterogeneous polysaccharide. It is extracted from various animal cartilages, thus has a wide range of molecular weights and different amounts and patterns of sulfation. Chondroitin sulfate has an excellent safety profile, and although various meta-analyses have concluded that it has a beneficial effect on symptoms and structure, others have concluded little or no benefit. This may be due, at least partly, to variations in the quality of the chondroitin sulfate used for a particular study. Chondroitin sulfate is available as pharmaceutical- and nutraceutical-grade products, and the latter have great variations in preparation, composition, purity and effects. Moreover, some products contain a negligible amount of chondroitin sulfate and among samples with reasonable amounts, in vitro testing showed widely varying effects. Of importance, although some showed anti-inflammatory effects, others demonstrated weak effects, and some instances were even pro-inflammatory. This could be related to contaminants, which depend on the origin, production and purification process. It is therefore vitally important that only pharmaceutical-grade chondroitin sulfate be used for treating osteoarthritis patientsca
• dc.format.mimetype application/pdfca
• dc.identifier.citation Martel-Pelletier J, Farran A, Montell E, Vergés J, Pelletier J-P. Discrepancies in Composition and Biological Effects of Different Formulations of Chondroitin Sulfate. Molecules. 2015; 20(3):4277-89. doi: 10.3390/molecules20034277.ca
• dc.identifier.doi http://dx.doi.org/10.3390/molecules20034277
• dc.identifier.issn 1420-3049
• dc.identifier.uri http://hdl.handle.net/10230/23361
• dc.language.iso engca
• dc.publisher MDPIca
• dc.relation.ispartof Molecules. 2015;20(3):4277-89
• dc.rights This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.other Reumatisme articular degeneratiuca
• dc.title Discrepancies in Composition and Biological Effects of Different Formulations of Chondroitin Sulfateca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca