Effect of low-dose radiotherapy on the circulating levels of paraoxonase-1-related variables and markers of inflammation in patients with COVID-19 pneumonia

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• dc.contributor.author Rodríguez-Tomás, F.
• dc.contributor.author Algara López, Manuel-Ignacio
• dc.contributor.author Arenas Prat, Meritxell
• dc.date.accessioned 2022-10-06T07:07:49Z
• dc.date.available 2022-10-06T07:07:49Z
• dc.date.issued 2022
• dc.description.abstract The aim of our study was to investigate the changes produced by low-dose radiotherapy (LDRT) in the circulating levels of the antioxidant enzyme paraoxonase-1 (PON1) and inflammatory markers in patients with COVID-19 pneumonia treated with LDRT and their interactions with clinical and radiological changes. Data were collected from the IPACOVID prospective clinical trial (NCT04380818). The study included 30 patients treated with a whole-lung dose of 0.5 Gy. Clinical follow-up, as well as PON1-related variables, cytokines, and radiological parameters were analyzed before LDRT, at 24 h, and 1 week after treatment. Twenty-five patients (83.3%) survived 1 week after LDRT. Respiratory function and radiological images improved in survivors. Twenty-four hours after LDRT, PON1 concentration significantly decreased, while transforming growth factor beta 1 (TGF-β1) increased with respect to baseline. One week after LDRT, patients had increased PON1 activities and lower PON1 and TGF-β1 concentrations compared with 24 h after LDRT, PON1 specific activity increased, lactate dehydrogenase (LDH), and C-reactive protein (CRP) decreased, and CD4+ and CD8+ cells increased after one week. Our results highlight the benefit of LDRT in patients with COVID-19 pneumonia and it might be mediated, at least in part, by an increase in serum PON1 activity at one week and an increase in TGF-β1 concentrations at 24 h.
• dc.format.mimetype application/pdf
• dc.identifier.citation Rodríguez-Tomàs E, Acosta JC, Torres-Royo L, De Febrer G, Baiges-Gaya G, Castañé H, et al. Effect of low-dose radiotherapy on the circulating levels of paraoxonase-1-related variables and markers of inflammation in patients with COVID-19 pneumonia. Antioxidants (Basel). 2022 Jun 16; 11(6): 1184. DOI: 10.3390/antiox11061184
• dc.identifier.doi http://dx.doi.org/10.3390/antiox11061184
• dc.identifier.issn 2076-3921
• dc.identifier.uri http://hdl.handle.net/10230/54290
• dc.language.iso eng
• dc.publisher MDPI
• dc.rights Copyright © 2022 by Rodríguez-Tomàs E, Acosta JC, Torres-Royo L, De Febrer G, Baiges-Gaya G, Castañé H. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword COVID-19 pneumonia
• dc.subject.keyword Chemokines
• dc.subject.keyword Low-dose radiation therapy
• dc.subject.keyword Paraoxonase-1
• dc.title Effect of low-dose radiotherapy on the circulating levels of paraoxonase-1-related variables and markers of inflammation in patients with COVID-19 pneumonia
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion