An oncospace for human cancers

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• dc.contributor.author Aguadé Gorgorió, Guim, 1991-
• dc.contributor.author Costa, José
• dc.contributor.author Solé Vicente, Ricard, 1962-
• dc.date.accessioned 2023-05-17T05:47:15Z
• dc.date.available 2023-05-17T05:47:15Z
• dc.date.issued 2023
• dc.description.abstract Human cancers comprise an heterogeneous array of diseases with different progression patterns and responses to therapy. However, they all develop within a host context that constrains their natural history. Since it occurs across the diversity of organisms, one can conjecture that there is order in the cancer multiverse. Is there a way to capture the broad range of tumor types within a space of the possible? Here we define the oncospace, a coordinate system that integrates the ecological, evolutionary and developmental components of cancer complexity. The spatial position of a tumor results from its departure from the healthy tissue along these three axes, and progression trajectories inform about the components driving malignancy across cancer subtypes. We postulate that the oncospace topology encodes new information regarding tumorigenic pathways, subtype prognosis, and therapeutic opportunities: treatment design could benefit from considering how to nudge tumors toward empty evolutionary dead ends in the oncospace.
• dc.description.sponsorship This work was supported by the Botı́n Foundation by Banco Santander through its Santander Universities Global Division, the Spanish Ministry of Economy and Competitiveness, grant FIS2016-77447-R MINECO/AEI/FEDER, a Postdoctoral Fellowship 2022 of the Fundación Ramón Areces, an AGAUR FI 2018 grant, and the Santa Fe Institute.
• dc.format.mimetype application/pdf
• dc.identifier.citation Aguadé‐Gorgorió G, Costa J, Solé R. An oncospace for human cancers. Bioessays. 2023 May;45(5):e2200215. DOI: 10.1002/bies.202200215
• dc.identifier.doi http://dx.doi.org/10.1002/bies.202200215
• dc.identifier.issn 0265-9247
• dc.identifier.uri http://hdl.handle.net/10230/56843
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof Bioessays. 2023 May;45(5):e2200215
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/FIS2016-77447-R
• dc.rights © 2023 The Authors. BioEssays published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Cancer morphospace
• dc.subject.keyword Developmental abnormalities
• dc.subject.keyword Genome instability
• dc.subject.keyword Microenvironmental complexity
• dc.title An oncospace for human cancers
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion