Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure
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- dc.contributor.author Gruzieva, Olenaca
- dc.contributor.author Antó i Boqué, Josep Mariaca
- dc.contributor.author Bustamante Pineda, Marionaca
- dc.contributor.author Guxens Junyent, Mònicaca
- dc.contributor.author Sunyer Deu, Jordica
- dc.contributor.author Melén, Erikca
- dc.date.accessioned 2017-03-03T09:51:08Z
- dc.date.available 2017-03-03T09:51:08Z
- dc.date.issued 2017
- dc.description.abstract BACKGROUND: Prenatal exposure to air pollution is considered to be associated with adverse effects on child health. This may partly be mediated by mechanisms related to DNA methylation. OBJECTIVES: We investigated associations between exposure to air pollution, using nitrogen dioxide (NO2) as marker, and epigenome-wide cord blood DNA methylation. METHODS: We meta-analyzed the associations between NO2 exposure at residential addresses during pregnancy and cord blood DNA methylation (Illumina 450K) in four European and North American studies (n = 1,508) with subsequent look-up analyses in children ages 4 (n = 733) and 8 (n = 786) years. Additionally, we applied a literature-based candidate approach for antioxidant and anti-inflammatory genes. To assess influence of exposure at the transcriptomics level, we related mRNA expression in blood cells to NO2 exposure in 4- (n = 111) and 16-year-olds (n = 239). RESULTS: We found epigenome-wide significant associations [false discovery rate (FDR) p < 0.05] between maternal NO2 exposure during pregnancy and DNA methylation in newborns for 3 CpG sites in mitochondria-related genes: cg12283362 (LONP1), cg24172570 (3.8 kbp upstream of HIBADH), and cg08973675 (SLC25A28). The associations with cg08973675 methylation were also significant in the older children. Further analysis of antioxidant and anti-inflammatory genes revealed differentially methylated CpGs in CAT and TPO in newborns (FDR p < 0.05). NO2 exposure at the time of biosampling in childhood had a significant impact on CAT and TPO expression. CONCLUSIONS: NO2 exposure during pregnancy was associated with differential offspring DNA methylation in mitochondria-related genes. Exposure to NO2 was also linked to differential methylation as well as expression of genes involved in antioxidant defense pathwaysca
- dc.format.mimetype application/pdfca
- dc.identifier.citation Gruzieva O, Xu CJ, Breton CV, Annesi-Maesano I, Antó JM, Auffray C. et al. Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure. Environ Health Perspect. 2017 Jan;125(1):104-110. doi: 10.1289/EHP36ca
- dc.identifier.doi http://dx.doi.org/10.1289/EHP36
- dc.identifier.issn 0091-6765
- dc.identifier.uri http://hdl.handle.net/10230/28166
- dc.language.iso engca
- dc.publisher Environmental health perspectivesca
- dc.relation.ispartof Environmental Health Perspectives. 2017 Jan;125(1):104-10
- dc.rights Reproduced with permission from Environmental Health Perspectivesca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Contaminació de l'aireca
- dc.subject.other Embaràsca
- dc.subject.other Anomalies congènitesca
- dc.title Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposureca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca