Thiol-based H2O2 signalling in microbial systems
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- dc.contributor.author Boronat i Llop, Susanna, 1965-ca
- dc.contributor.author Domènech, Albaca
- dc.contributor.author Paulo Mirasol, Esther, 1984-ca
- dc.contributor.author Calvo, Isabel A.ca
- dc.contributor.author García Santamarina, Sarela, 1978-ca
- dc.contributor.author García, Patríciaca
- dc.contributor.author Encinar del Dedo, Javierca
- dc.contributor.author Barcons-Simon, Annaca
- dc.contributor.author Serrano, Ericaca
- dc.contributor.author Carmona, Mercèca
- dc.contributor.author Hidalgo Hernando, Elenaca
- dc.date.accessioned 2015-06-18T07:03:35Z
- dc.date.available 2015-06-18T07:03:35Z
- dc.date.issued 2014ca
- dc.description.abstract Cysteine residues, and in particular their thiolate groups, react not only with reactive oxygen species but also with electrophiles and with reactive nitrogen species. Thus, cysteine oxidation has often been linked to the toxic effects of some of these reactive molecules. However, thiol-based switches are common in protein sensors of antioxidant cascades, in both prokaryotic and eukaryotic organisms. We will describe here three redox sensors, the transcription factors OxyR, Yap1 and Pap1, which respond by disulfide bond formation to hydrogen peroxide stress, focusing specially on the differences among the three peroxide-sensing mechanisms.en
- dc.description.sponsorship This work was supported by the Spanish Ministry of Science and Innovation (BFU2009-06933 and BFU2012-32045), PLAN E and FEDER, by the Spanish Program Consolider-Ingenio 2010 Grant CSD 2007-0020, and by SGR2009-195 from Generalitat de Catalunya (Spain) to E.H. E. H. is recipient of an ICREA Academia Award (Generalitat de Catalunya).en
- dc.format.mimetype application/pdfca
- dc.identifier.citation Boronat S, Domènech A, Paulo E, Calvo IA, García-Santamarina S, García P et al. Thiol-based H2O2 signalling in microbial systems. Redox Biology. 2014;2:395-9. DOI: 10.1016/j.redox.2014.01.015
- dc.identifier.doi http://dx.doi.org/10.1016/j.redox.2014.01.015
- dc.identifier.issn 2213-2317ca
- dc.identifier.uri http://hdl.handle.net/10230/23855
- dc.language.iso engca
- dc.publisher Elsevierca
- dc.relation.ispartof Redox Biology. 2014;2:395-9
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2009-06933
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-32045
- dc.rights © 2014 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/)en
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/
- dc.subject.keyword H2O2 sensoren
- dc.subject.keyword Cys oxidationen
- dc.subject.keyword OxyRen
- dc.subject.keyword Pap1en
- dc.subject.keyword Yap1en
- dc.subject.keyword S. pombeen
- dc.subject.other Escheríchia colica
- dc.subject.other Saccharomyces cerevisiae -- Metabolismeca
- dc.subject.other Schizosaccharomyces pombe -- Metabolismeca
- dc.title Thiol-based H2O2 signalling in microbial systemsen
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca