Particulate matter exposure during pregnancy and childhood leukemia incidence
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- dc.contributor.author Sanz Olea, Enrique
- dc.contributor.author Ojeda Sánchez, Carlos
- dc.contributor.author Guxens Junyent, Mònica
- dc.contributor.author Cañete, Adela
- dc.contributor.author Pardo Romaguera, Elena
- dc.contributor.author Gómez-Barroso, Diana
- dc.contributor.author García-Pérez, Javier
- dc.contributor.author Nuñez-Corcuera, Beatriz
- dc.contributor.author Ortega-García, Juan Antonio
- dc.contributor.author Ramis, Rebeca
- dc.date.accessioned 2024-11-18T07:14:16Z
- dc.date.available 2024-11-18T07:14:16Z
- dc.date.issued 2024
- dc.description.abstract Leukemia is the most common childhood cancer and its etiology could be related to various environmental contaminants such as particulate matter (PM). The objective of our study is to evaluate the potential association between exposure to PM during pregnancy and the incidence of childhood leukemia. We established a population-based nationwide cohort using the Spanish Birth Registry Statistics database of the National Statistics Institute. We used spatiotemporal land use random forest models to estimate the concentrations of PM10 and PM2.5 for the entire pregnancy and by trimesters. We conducted logistic regression analyses adjusted for various covariates. In addition, we fitted generalized additive models (GAMs) to estimate the non-linear relationship between PM levels and leukemia incidence. The study included 3,112,123 children and 1066 cases of leukemia. The results for the continuous variable of PM10 exposure levels suggested an increased risk of childhood leukemia to be associated with higher exposure. The results for the categorized PM10 variable suggest an increased risk of childhood leukemia among pregnant women whose exposure levels were higher than the median (third and fourth quartiles). The results for PM2.5 were weaker. We found association between exposure to PM10 during pregnancy and an increased risk of childhood leukemia. Our findings indicate that public health interventions should aim to reduce air pollution to lower the incidence of childhood leukemia.
- dc.format.mimetype application/pdf
- dc.identifier.citation Sanz Olea E, Ojeda Sanchez C, Guxens M, Cañete A, Pardo Romaguera E, Gómez-Barroso D, et al. Particulate matter exposure during pregnancy and childhood leukemia incidence. Atmosphere. 2024;15(7):751. DOI: 10.3390/atmos15070751
- dc.identifier.doi http://dx.doi.org/10.3390/atmos15070751
- dc.identifier.issn 2073-4433
- dc.identifier.uri http://hdl.handle.net/10230/68711
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Atmosphere. 2024;15(7):751
- dc.rights © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword PM10
- dc.subject.keyword PM2.5
- dc.subject.keyword Environmental factors
- dc.subject.keyword Childhood cancer
- dc.subject.keyword Childhood leukemia
- dc.subject.keyword Incidence
- dc.subject.keyword Epidemiology
- dc.title Particulate matter exposure during pregnancy and childhood leukemia incidence
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion