Telomere length but not mitochondrial DNA copy number is altered in both young and old COPD

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  • dc.contributor.author Casas-Recasens, Sandra
  • dc.contributor.author Mendoza, Nuria
  • dc.contributor.author López-Giraldo, Alejandra
  • dc.contributor.author Garcia, Tamara
  • dc.contributor.author Cosio, Borja G.
  • dc.contributor.author Pascual Guàrdia, Sergi, 1979-
  • dc.contributor.author Acosta-Castro, Ady
  • dc.contributor.author Borrás Santos, Alícia, 1974-
  • dc.contributor.author Gea Guiral, Joaquim
  • dc.contributor.author Garrabou, Glòria
  • dc.contributor.author Agustí García-Navarro, Àlvar
  • dc.contributor.author Faner, Rosa
  • dc.date.accessioned 2022-01-19T07:44:52Z
  • dc.date.available 2022-01-19T07:44:52Z
  • dc.date.issued 2021
  • dc.description.abstract Accelerated ageing is implicated in the pathogenesis of respiratory diseases as chronic obstructive pulmonary disease (COPD), but recent evidence indicates that the COPD can have roots early in life. Here we hypothesise that the accelerated ageing markers might have a role in the pathobiology of young COPD. The objective of this study was to compare two hallmarks of ageing, telomere length (TL), and mitochondrial DNA copy number (mtDNA-CN, as a surrogate marker of mitochondrial dysfunction) in young (≤ 50 years) and old (>50 years) smokers, with and without COPD. Both, TL and mtDNA-CN were measured in whole blood DNA by quantitative PCR [qPCR] in: (1) young ever smokers with (n = 81) or without (n = 166) COPD; and (2) old ever smokers with (n = 159) or without (n = 29) COPD. A multivariable linear regression was used to assess the association of TL and mtDNA-CN with lung function. We observed that in the entire study population, TL and mtDNA-CN decreased with age, and the former but not the latter related to FEV1/FVC (%), FEV1 (% ref.), and DLCO (% ref.). The short telomeres were found both in the young and old patients with severe COPD (FEV1 <50% ref.). In addition, we found that TL and mtDNA-CN were significantly correlated, but their relationship was positive in younger while negative in the older patients with COPD, suggesting a mitochondrial dysfunction. We conclude that TL, but not mtDNA-CN, is associated with the lung function impairment. Both young and old patients with severe COPD have evidence of accelerated ageing (shorter TL) but differ in the direction of the correlation between TL and mtDNA-CN in relation to age.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Casas-Recasens S, Mendoza N, López-Giraldo A, Garcia T, Cosio BG, Pascual-Guardia S, Acosta-Castro A, Borras-Santos A, Gea J, Garrabou G, Agusti A, Faner R. Telomere length but not mitochondrial DNA copy number is altered in both young and old COPD. Front Med (Lausanne). 2021;8:761767. DOI: 10.3389/fmed.2021.761767
  • dc.identifier.doi http://dx.doi.org/10.3389/fmed.2021.761767
  • dc.identifier.issn 2296-858X
  • dc.identifier.uri http://hdl.handle.net/10230/52255
  • dc.language.iso eng
  • dc.publisher Frontiers
  • dc.relation.ispartof Front Med (Lausanne). 2021;8:761767
  • dc.rights © 2021 Casas-Recasens, Mendoza, López-Giraldo, Garcia, Cosio, Pascual-Guardia, Acosta-Castro, Borras-Santos, Gea, Garrabou, Agusti and Faner. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Ageing
  • dc.subject.keyword Chronic bronchitis
  • dc.subject.keyword Emphysema
  • dc.subject.keyword Mitochondrial DNA
  • dc.subject.keyword Telomeres
  • dc.title Telomere length but not mitochondrial DNA copy number is altered in both young and old COPD
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Departament de Medicina i Ciències de la Vida)
Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Articles (Hospital del Mar Research Institute)