Inflammatory potential of diet and bone mineral density in a senior mediterranean population: a cross-sectional analysis of PREDIMED-Plus study

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  • dc.contributor.author García-Gavilán, Jesús Francisco
  • dc.contributor.author Paz-Graniel, Indira
  • dc.contributor.author Babio, Nancy
  • dc.contributor.author Romaguera Bosch, Dora
  • dc.contributor.author Martínez, José Alfredo
  • dc.contributor.author Martín, Vicente
  • dc.contributor.author Martínez, María Ángeles
  • dc.contributor.author Konieczna, Jadwiga
  • dc.contributor.author Ruiz-Canela, Miguel
  • dc.contributor.author de Paz Fernández, José Antonio
  • dc.contributor.author Goday Arno, Alberto
  • dc.contributor.author Martínez-González, Miguel Ángel, 1957-
  • dc.contributor.author Bulló, Mònica
  • dc.contributor.author Salas Salvadó, Jordi
  • dc.date.accessioned 2022-07-27T06:21:44Z
  • dc.date.available 2022-07-27T06:21:44Z
  • dc.date.issued 2022
  • dc.description.abstract Purpose: inflammation could play a key role in tissue damage and bone metabolism. The modified dietary inflammatory score (M-DIS) is a validated tool to estimate the inflammatory potential of the diet. In the present study, we evaluate the associations between the M-DIS and bone mineral density (BMD) in a senior Mediterranean population with overweight/obesity and metabolic syndrome. Methods: baseline cross-sectional association between the M-DIS and bone mineral density was assessed in 1134 participants of the multicenter PREDIMED-Plus trial (aged 55-75 with overweight/obesity and metabolic syndrome). BMD was measured using Dual-energy X-ray Absorptiometry scans and participants answered a food frequency questionnaire to determine the M-DIS. BMD was categorized as low BMD when T score was equal or lower than -1 and normal BMD in another case. Associations between BMD and M-DIS were evaluated by using linear and logistic regressions adjusted by other co-variates. Results: participants in the top tertile of the M-DIS had a lower BMD at total femur [β (95% CI) - 0.02 (- 0.04, - 0.01)], trochanter areas [β (95% CI) - 0.03 (- 0.05, - 0.01)] and lumbar spine area [β (95% CI) - 0.03 (- 0.07, 0.01)] (but in the last case, measures were less precise and hence not statistically significant) compared to those in the lower M-DIS tertile. Multiple logistic regression analyses showed that the odds of the total femur and femoral trochanter osteopenia/osteoporosis were higher in participants in the top tertile compared to those in the lowest tertile of M-DIS [OR (95% CI) 1.71 (1.12, 2.64), P for trend 0.015; 2.02 (1.29, 3.21), P for trend 0.002, respectively]. Conclusion: a high pro-inflammatory diet, measured by the M-DIS, is associated with lower BMD in a senior Mediterranean population with metabolic syndrome.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation García-Gavilán JF, Paz-Graniel I, Babio N, Romaguera D, Martínez JA, Martin V, et al. Inflammatory potential of diet and bone mineral density in a senior mediterranean population: a cross-sectional analysis of PREDIMED-Plus study. Eur J Nutr. 2022 Apr; 61 (3):1445-55. DOI: 10.1007/s00394-021-02751-5
  • dc.identifier.doi http://dx.doi.org/10.1007/s00394-021-02751-5
  • dc.identifier.issn 1436-6207
  • dc.identifier.uri http://hdl.handle.net/10230/53832
  • dc.language.iso eng
  • dc.publisher SpringerOpen
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/340918
  • dc.rights Copyright © García-Gavilán JF, Paz-Graniel I, Babio N, Romaguera D, Martínez JA, Martin V, 2021. Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Bone mineral density
  • dc.subject.keyword Diet
  • dc.subject.keyword Inflammation
  • dc.subject.keyword Osteoporosis
  • dc.title Inflammatory potential of diet and bone mineral density in a senior mediterranean population: a cross-sectional analysis of PREDIMED-Plus study
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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