Stress-induced cell depolarization through the MAP kinase-Cdc42 axis

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• dc.contributor.author Salat Canela, Clàudia, 1989-
• dc.contributor.author Pérez, Pilar
• dc.contributor.author Ayté del Olmo, José
• dc.contributor.author Hidalgo Hernando, Elena
• dc.date.accessioned 2023-01-25T07:32:36Z
• dc.date.issued 2022
• dc.description.abstract General stress responses, which sense environmental or endogenous signals, aim at promoting cell survival and fitness during adverse conditions. In eukaryotes, mitogen-activated protein (MAP) kinase-driven cascades trigger a shift in the cell's gene expression program as a cellular adaptation to stress. Here, we review another aspect of activated MAP kinase cascades reported in fission yeast: the transient inhibition of cell polarity in response to oxidative stress. The phosphorylation by a stress-activated MAP kinase of regulators of the GTPase cell division cycle 42 (Cdc42) causes a transient inhibition of polarized cell growth. The formation of growth sites depends on limiting and essential polarity components. We summarize here some processes in which inhibition of Cdc42 may be a general mechanism to regulate polarized growth also under physiological conditions.
• dc.description.sponsorship This work is supported by grant PGC2018-093920-B-I00 to E.H. and PGC2018-097248-B-I00 to J.A., funded by MCIN/AEI/10.13039/501100011033 and by ‘European Regional Development Fund (ERDF) A way of making Europe’, by the ‘European Union’. The Oxidative Stress and Cell Cycle group is also supported by Generalitat de Catalunya (Spain) (2017-SGR-539) and by Excellence Unit “María de Maeztu” Grant CEX2018-000792-M funded by MCIN/AEI/10.13039/501100011033. E.H. is a recipient of an ICREA Academia Award (Generalitat de Catalunya, Spain). P.P. was supported by grants CSI150P20 and ‘Escalera de Excelencia’ CLU-2017-03 (Junta de Castilla y Leon, Spain; and the European Regional Development Fund, FEDER, EU). C.S-C. was a recipient of a María de Maeztu predoctoral fellowship from the Ministerio de Economía y Competitividad (Spain).
• dc.format.mimetype application/pdf
• dc.identifier.citation Salat-Canela C, Pérez P, Ayté J, Hidalgo E. Stress-induced cell depolarization through the MAP kinase-Cdc42 axis. Trends Cell Biol. 2023 Feb;33(2):124-37. DOI: 10.1016/j.tcb.2022.06.004
• dc.identifier.doi http://dx.doi.org/10.1016/j.tcb.2022.06.004
• dc.identifier.issn 0962-8924
• dc.identifier.uri http://hdl.handle.net/10230/55430
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Trends Cell Biol. 2023 Feb;33(2):124-37
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-093920-B-I00
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-097248-B-I00
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.tcb.2022.06.004
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Cdc42
• dc.subject.keyword MAP kinase
• dc.subject.keyword Inhibition of cell polarity
• dc.subject.keyword Oxidative stress response
• dc.subject.keyword Phosphorylation of GAPs and GEFs
• dc.title Stress-induced cell depolarization through the MAP kinase-Cdc42 axis
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion