Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain

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• dc.contributor.author Fernández de Larrea-Baz, Nereaca
• dc.contributor.author Castaño Vinyals, Gemmaca
• dc.contributor.author Kogevinas, Manolisca
• dc.contributor.author Aragonés, Núriaca
• dc.date.accessioned 2018-05-28T07:35:58Z
• dc.date.available 2018-05-28T07:35:58Z
• dc.date.issued 2017
• dc.description.abstract Background: Several studies have suggested that Helicobacter pylori (H. pylori) infection is a risk factor for colorectal cancer (CRC), while others have not confirmed this hypothesis. This work aimed to assess the relation of CRC with H. pylori seropositivity and with seropositivity to 16 H. pylori proteins, in the MultiCase-Control study, MCC-Spain. Methods: MCC-Spain is a multicase-control study carried out in Spain from 2008 to 2013. In total, 2,140 histologically-confirmed incident CRC cases and 4,098 population-based controls were recruited. Controls were frequency-matched by sex, age, and province. Epidemiological data were collected through a questionnaire fulfilled by face-to-face interviews and a self-administered food-frequency questionnaire. Seroreactivities against 16 H. pylori proteins were determined in 1,488 cases and 2,495 controls using H. pylori multiplex serology. H. pylori seropositivity was defined as positivity to ≥4 proteins. Multivariable logistic regression mixed models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results:H. pylori seropositivity was not associated with increased CRC risk (OR = 0.91; 95% CI: 0.71-1.16). Among H. pylori seropositive subjects, seropositivity to Cagδ showed a lower CRC risk, and risk decreased with increasing number of proteins seropositive. Seropositivity to the most recognized virulence factors, CagA and VacA, was not associated with a higher CRC risk. No statistically significant heterogeneity was identified among tumor sites, although inverse relations were stronger for left colon cancer. An interaction with age and sex was found: H. pylori seropositivity was associated with a lower CRC risk in men younger than 65 and with a higher risk in older women. Conclusions: Our results suggest that neither H. pylori seropositivity, nor seropositivity to the virulence factor CagA are associated with a higher CRC risk. A possible effect modification by age and sex was identified.
• dc.format.mimetype application/pdf
• dc.identifier.citation Fernández de Larrea-Baz N, Michel A, Romero B, Pérez-Gómez B, Moreno V, Martín V et al. Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain. Front Microbiol. 2017 May 29;8:888. DOI: 10.3389/fmicb.2017.00888
• dc.identifier.doi http://dx.doi.org/10.3389/fmicb.2017.00888
• dc.identifier.issn 1664-302X
• dc.identifier.uri http://hdl.handle.net/10230/34737
• dc.language.iso eng
• dc.publisher Frontiersca
• dc.relation.ispartof Frontiers in Microbiology. 2017 May 29;8:888
• dc.rights © 2017 Fernández de Larrea-Baz, Michel, Romero, Pérez-Gómez, Moreno, Martín, Dierssen-Sotos, Jiménez-Moleón, Castilla, Tardón, Ruiz, Peiró, Tejada, Chirlaque, Butt, Olmedo-Requena, Gómez-Acebo, Linares, Boldo, Castells, Pawlita, Castaño-Vinyals, Kogevinas, de Sanjosé, Pollán, del Campo, Waterboer and Aragonés. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Helicobacter pylori
• dc.subject.keyword Bacterial infections
• dc.subject.keyword Chronic infection
• dc.subject.keyword Colorectal neoplasm
• dc.subject.keyword Multiplex serology
• dc.subject.keyword Non-infectious diseases
• dc.subject.other Helicobacteri pilòric
• dc.title Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spainca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion