Eosinophil count and neutrophil-lymphocyte count ratio as prognostic markers in patients with bacteremia: a retrospective cohort study

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• dc.contributor.author Terradas Robledo, Roser
• dc.contributor.author Grau Cerrato, Santiago
• dc.contributor.author Blanch, Jordi
• dc.contributor.author Riu Camps, Marta
• dc.contributor.author Saballs, Pere
• dc.contributor.author Castells, Xavier
• dc.contributor.author Horcajada Gallego, Juan Pablo
• dc.contributor.author Knobel Freud, Hernando
• dc.date.accessioned 2025-01-13T08:52:08Z
• dc.date.available 2025-01-13T08:52:08Z
• dc.date.issued 2012
• dc.description.abstract Introduction: There is scarce evidence on the use of eosinophil count as a marker of outcome in patients with infection. The aim of this study was to evaluate whether changes in eosinophil count, as well as the neutrophil-lymphocyte count ratio (NLCR), could be used as clinical markers of outcome in patients with bacteremia. Methods: We performed a retrospective study of patients with a first episode of community-acquired or healthcare-related bacteremia during hospital admission between 2004 and 2009. A total of 2,311 patients were included. Cox regression was used to analyze the behaviour of eosinophil count and the NLCR in survivors and non-survivors. Results: In the adjusted analysis, the main independent risk factor for mortality was persistence of an eosinophil count below 0.0454·10(3)/uL (HR = 4.20; 95% CI 2.66-6.62). An NLCR value >7 was also an independent risk factor but was of lesser importance. The mean eosinophil count in survivors showed a tendency to increase rapidly and to achieve normal values between the second and third day. In these patients, the NLCR was <7 between the second and third day. Conclusion: Both sustained eosinopenia and persistence of an NLCR >7 were independent markers of mortality in patients with bacteremia.
• dc.format.mimetype application/pdf
• dc.identifier.citation Terradas R, Grau S, Blanch J, Riu M, Saballs P, Castells X, et al. Eosinophil count and neutrophil-lymphocyte count ratio as prognostic markers in patients with bacteremia: a retrospective cohort study. PLoS One. 2012;7(8):e42860. DOI: 10.1371/journal.pone.0042860
• dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0042860
• dc.identifier.issn 1932-6203
• dc.identifier.uri http://hdl.handle.net/10230/69083
• dc.language.iso eng
• dc.publisher Public Library of Science (PLoS)
• dc.relation.ispartof PLoS One. 2012;7(8):e42860
• dc.rights © Terradas et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Eosinophils
• dc.subject.keyword Bacteremia
• dc.subject.keyword Death rates
• dc.subject.keyword Blood
• dc.subject.keyword Blood counts
• dc.subject.keyword Bacterial diseases
• dc.subject.keyword Medical risk factors
• dc.subject.keyword White blood cells
• dc.title Eosinophil count and neutrophil-lymphocyte count ratio as prognostic markers in patients with bacteremia: a retrospective cohort study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion