Socioeconomic inequalities in the external exposome in European cohorts: The EXPANSE project

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• dc.contributor.author Saucy, Apolline
• dc.contributor.author Coloma, Fabián
• dc.contributor.author Olmos, Sergio
• dc.contributor.author Dadvand, Payam
• dc.contributor.author Nieuwenhuijsen, Mark J.
• dc.contributor.author Tonne, Cathryn
• dc.contributor.author EXPANSE Project Team
• dc.date.accessioned 2024-11-22T11:37:03Z
• dc.date.available 2024-11-22T11:37:03Z
• dc.date.issued 2024
• dc.description.abstract Socioeconomic inequalities in the exposome have been found to be complex and highly context-specific, but studies have not been conducted in large population-wide cohorts from multiple countries. This study aims to examine the external exposome, encompassing individual and environmental factors influencing health over the life course, and to perform dimension reduction to derive interpretable characterization of the external exposome for multicountry epidemiological studies. Analyzing data from over 25 million individuals across seven European countries including 12 administrative and traditional cohorts, we utilized domain-specific principal component analysis (PCA) to define the external exposome, focusing on air pollution, the built environment, and air temperature. We conducted linear regression to estimate the association between individual- and area-level socioeconomic position and each domain of the external exposome. Consistent exposure patterns were observed within countries, indicating the representativeness of traditional cohorts for air pollution and the built environment. However, cohorts with limited geographical coverage and Southern European countries displayed lower temperature variability, especially in the cold season, compared to Northern European countries and cohorts including a wide range of urban and rural areas. The individual- and area-level socioeconomic determinants (i.e., education, income, and unemployment rate) of the urban exposome exhibited significant variability across the European region, with area-level indicators showing stronger associations than individual variables. While the PCA approach facilitated common interpretations of the external exposome for air pollution and the built environment, it was less effective for air temperature. The diverse socioeconomic determinants suggest regional variations in environmental health inequities, emphasizing the need for targeted interventions across European countries.
• dc.description.sponsorship The EXPANSE project is funded by the European Union’s Horizon 2020 research and innovation program under grant agreement no. 874627. This research has received funding from the EXPOSOME-NL Gravitation program of the Dutch Ministry of Education, Culture, and Science and The Netherlands Organisation for Scientific Research (NWO grant number 024.004.017). We acknowledge support from the Spanish Ministry of Science and Innovation and State Research Agency through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S) and from the Generalitat de Catalunya through the CERCA Program. AS has received funding from the Swiss National Science Foundation (grant number 210781). We acknowledge collaborators involved in the EXPANSE project and those who participated in the cohort data collection and preparation for this research. The PIAMA study has received funding from the Dutch Lung Foundation; The Netherlands Organisation for Health Research and Development; The Dutch Research Council (NWO); The Netherlands Ministry of Spatial Planning, Housing, and the Environment; The Netherlands Ministry of Health, Welfare, and Sport; and the National Institute for Public Health and the Environment. The AMIGO cohort was funded by The Netherlands Organisation for Health Research and Development (ZonMw) within the Electromagnetic Fields and Health Research program (grant numbers 85200001, 85200002, 85500003, and 85800001). The BAMSE study was supported by grants from the Swedish Research Council (2016-03086; 2020-01886) and the Swedish Heart-Lung Foundation, Region Stockholm (ALF project and for cohort and database maintenance). The KORA study was initiated and financed by the Helmholtz Zentrum München─German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research (BMBF) and by the State of Bavaria. Data collection in the KORA study is done in cooperation with the University Hospital of Augsburg. This study makes use of data generated by the GCAT, Fundacio IGTP. IGTP is part of the CERCA Program/Generalitat de Catalunya. Initially funded by Acción de Dinamización del ISCIII-MINECO and the Ministry of Health of the Generalitat of Catalunya (ADE 10/00026), we had additional support from Spanish National Grant PI18/01512. The authors of the study would like to acknowledge all GCAT project investigators who contributed to the generation of the GCAT data. A full list of the investigators is available from www.genomesforlife.com, especially we thank former ones, Anna Carreras and Beatriz Cortés. We thank Dr. Joan Grifols on behalf of the Blood and Tissue Bank from Catalonia (BST) and all the GCAT volunteers who participated in the study. We thank the GREEK e-Government Center for Social Security Services (IDIKA SA) for allowing the analysis of the Greek national administrative cohort data. We thank the Hellenic Statistical Authority for providing the area-level socio-demographic data. We thank the Swiss Federal Statistical Office for providing mortality and census data and for the support that made the Swiss National Cohort possible. We also acknowledge the members of the Swiss National Cohort Study Group: Matthias Egger (Chairman of the Executive Board), Adrian Spoerri and Marcel Zwahlen (all Bern), Milo Puhan (Chairman of the Scientific Board), Matthias Bopp (both Zurich), Martin Roosli (Basel), Murielle Bochud (Lausanne), and Michel Oris (Geneva). We thank the Public Data Analysis for Health Research and Innovation Program of Catalonia for its support with the Catalonia cohort. The EPIC-NL cohort was supported by the “Europe against Cancer” Program of the European Commission (DG-SANCO); the Dutch Ministry of Public Health, Welfare, and Sports; the Dutch Ministry of Economic Affairs; the Dutch Cancer Society; ZonMw (The Netherlands Organisation for Health Research and Development); and the World Cancer Research Fund (WCRF). The Umeå SIMSAM Lab data infrastructure used in this study was developed with support from the Swedish Research Council, the Riksbankens Jubileumsfond, and strategic funds from Umeå University.
• dc.format.mimetype application/pdf
• dc.identifier.citation Saucy A, Coloma F, Olmos S, Åström C, Blay N, Boer JMA, et al. Socioeconomic inequalities in the external exposome in European cohorts: The EXPANSE project. Environ Sci Technol. 2024 Sep 17;58(37):16248-57. DOI: 10.1021/acs.est.4c01509
• dc.identifier.doi http://dx.doi.org/10.1021/acs.est.4c01509
• dc.identifier.issn 0013-936X
• dc.identifier.uri http://hdl.handle.net/10230/68786
• dc.language.iso eng
• dc.publisher American Chemical Society (ACS)
• dc.relation.ispartof Environ Sci Technol. 2024 Sep 17;58(37):16248-57
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874627
• dc.rights © 2024 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY 4.0 (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword European cohorts
• dc.subject.keyword Environmental health equity
• dc.subject.keyword External exposome
• dc.subject.keyword Socioeconomic determinants
• dc.title Socioeconomic inequalities in the external exposome in European cohorts: The EXPANSE project
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion