PI-CT: design, challenges and epidemiological methods of an international study on cancer risk after paediatric and young adult CT

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• dc.contributor.author Bosch de Basea i Gómez, Magda, 1982-
• dc.contributor.author Vrijheid, Martine
• dc.contributor.author Cardis, Elisabeth
• dc.date.accessioned 2023-11-20T08:23:20Z
• dc.date.available 2023-11-20T08:23:20Z
• dc.date.issued 2015
• dc.description.abstract Computed tomography (CT) has great clinical utility and its usage has increased dramatically over the years. Concerns have been raised, however, about health impacts of ionising radiation exposure from CTs, particularly in children, who have a higher risk for some radiation induced diseases. Direct estimation of the health impact of these exposures is needed, but the conduct of epidemiological studies of paediatric CT populations poses a number of challenges which, if not addressed, could invalidate the results. The aim of the present paper is to review the main challenges of a study on the health impact of paediatric CTs and how the protocol of the European collaborative study EPI-CT, coordinated by the International Agency for Research on Cancer (IARC), is designed to address them. The study, based on a common protocol, is being conducted in Belgium, Denmark, France, Germany, the Netherlands, Norway, Spain, Sweden and the United Kingdom and it has recruited over one million patients suitable for long-term prospective follow-up. Cohort accrual relies on records of participating hospital radiology departments. Basic demographic information and technical data on the CT procedure needed to estimate organ doses are being abstracted and passive follow-up is being conducted by linkage to population-based cancer and mortality registries. The main issues which may affect the validity of study results include missing doses from other radiological procedures, missing CTs, confounding by CT indication and socioeconomic status and dose reconstruction. Sub-studies are underway to evaluate their potential impact. By focusing on the issues which challenge the validity of risk estimates from CT exposures, EPI-CT will be able to address limitations of previous CT studies, thus providing reliable estimates of risk of solid tumours and leukaemia from paediatric CT exposures and scientific bases for the optimisation of paediatric CT protocols and patient protection.
• dc.description.sponsorship This work was supported by the European Community's Seventh Framework Programme (FP7/2007–2013) (grant number 269912 - EPI-CT: Epidemiological study to quantify risks for paediatric computerised tomography and to optimise doses). The International Agency for Research in Cancer (IARC) received complementary funding from the Ministry of Health, Labour and Welfare of Japan (grant agreement number 2012-02-21-01). In France, complementary funding was obtained from the French national Institute of Cancer and from the Association 'La ligue contre le Cancer'. Complementary funding was received from the German Federal Ministry of Education and Research [grant number 02NUK016] for the German KICT study. In Spain, complementary funding was received from a the Consejo de Seguridad Nuclear and M Bosch de Basea was the recipient of a fellowship of the Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP) for a short stay abroad at Newcastle University. In The Netherlands Worlwide Cancer Research, formerly known as the Association for International Cancer Research, provided partial funding [Grant 12–1155]. The original United Kingdom cohort study was funded by the United Kingdom Department of Health and the United States National Cancer Institute and further funding for the study has been obtained from Cancer Research UK. In Norway, it was funded by the Norwegian Research Council through the EURATOM programme, project no. 209096/E40.
• dc.format.mimetype application/pdf
• dc.identifier.citation Bosch de Basea M, Pearce MS, Kesminiene A, Bernier MO, Dabin J, Engels H, et al. EPI-CT: design, challenges and epidemiological methods of an international study on cancer risk after paediatric and young adult CT. J Radiol Prot. 2015 Sep;35(3):611-28. DOI: 10.1088/0952-4746/35/3/611
• dc.identifier.doi http://dx.doi.org/10.1088/0952-4746/35/3/611
• dc.identifier.issn 0952-4746
• dc.identifier.uri http://hdl.handle.net/10230/58308
• dc.language.iso eng
• dc.publisher IOP Publishing Ltd.
• dc.relation.ispartof Journal of Radiological Protection. 2015 Sep;35(3):611-28
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/269912
• dc.rights Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/3.0/
• dc.subject.keyword CT scan
• dc.subject.keyword Cohort study
• dc.subject.keyword Epidemiological methods
• dc.subject.keyword Cancer
• dc.subject.keyword Leukaemia
• dc.title PI-CT: design, challenges and epidemiological methods of an international study on cancer risk after paediatric and young adult CT
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion