New genes and functional innovation in mammals
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- dc.contributor.author Villanueva Cañas, José Luis, 1984-ca
- dc.contributor.author Ruiz Orera, Jorge, 1988-ca
- dc.contributor.author Agea, M. Isabelca
- dc.contributor.author Gallo, María, 1989-ca
- dc.contributor.author Andreu Martínez, Davidca
- dc.contributor.author Albà Soler, Marca
- dc.date.accessioned 2017-10-26T07:45:14Z
- dc.date.available 2017-10-26T07:45:14Z
- dc.date.issued 2017
- dc.description.abstract The birth of genes that encode new protein sequences is a major source of evolutionary innovation. However, we still understand relatively little about how these genes come into being and which functions they are selected for. To address these questions, we have obtained a large collection of mammalian-specific gene families that lack homologues in other eukaryotic groups. We have combined gene annotations and de novo transcript assemblies from 30 different mammalian species, obtaining ∼6,000 gene families. In general, the proteins in mammalian-specific gene families tend to be short and depleted in aromatic and negatively charged residues. Proteins which arose early in mammalian evolution include milk and skin polypeptides, immune response components, and proteins involved in reproduction. In contrast, the functions of proteins which have a more recent origin remain largely unknown, despite the fact that these proteins also have extensive proteomics support. We identify several previously described cases of genes originated de novo from noncoding genomic regions, supporting the idea that this mechanism frequently underlies the evolution of new protein-coding genes in mammals. Finally, we show that most young mammalian genes are preferentially expressed in testis, suggesting that sexual selection plays an important role in the emergence of new functional genes.
- dc.description.sponsorship The work was funded by grants BFU2012-36820 and BFU2015-65235-P from Ministerio de Economía e Innovación (Spanish Government) and co-funded by FEDER. We also received funding from Agència de Gestió d’Ajuts Universitaris i de Recerca Generatlitat de Catalunya (AGAUR), grant number 2014SGR1121
- dc.format.mimetype application/pdfca
- dc.identifier.citation Villanueva-Cañas JL, Ruiz-Orera J, Agea MI, Gallo M, Andreu D, Albà MM. New genes and functional innovation in mammals. Genome Biol Evol. 2017 Jul 1;9(7):1886-1900. DOI: 10.1093/gbe/evx136
- dc.identifier.doi http://dx.doi.org/10.1093/gbe/evx136
- dc.identifier.issn 1759-6653
- dc.identifier.uri http://hdl.handle.net/10230/33095
- dc.language.iso eng
- dc.publisher Oxford University Pressca
- dc.relation.ispartof Genome Biol Evol. 2017 Jul 1;9(7):1886-1900
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-36820
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2015-65235-P
- dc.rights © The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
- dc.subject.keyword Evolutionary innovation
- dc.subject.keyword Adaptive evolution
- dc.subject.keyword Mammals
- dc.title New genes and functional innovation in mammalsca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion