Identifying protein-coding genes in genomic sequences

Harrow, Jennifer; Nagy, Alinda; Reymond, Alexandre; Alioto, Tyler; Patthy, Laszlo; Antonarakis, Stylianos E.; Guigó Serra, Roderic

doi:http://dx.doi.org/10.1186/gb-2009-10-1-201

Identifying protein-coding genes in genomic sequences

Citation

Harrow J, Nagy A, Reymond A, Alioto T, Patthy L, Antonarakis S E, Guigó R. Identifying protein-coding genes in genomic sequences. Genome Biology. 2009;10:201. DOI: 10.1186/gb-2009-10-1-201

Abstract

The vast majority of the biology of a newly sequenced genome is inferred from the set of encoded proteins. Predicting this set is therefore invariably the first step after the completion of the genome DNA sequence. Here we review the main computational pipelines used to generate the human reference protein-coding gene sets.