Lifestyles, left atrial structure and function, and cognitive decline in adults with metabolic syndrome

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• dc.contributor.author González Casanova, Inés
• dc.contributor.author Alonso-Gómez, Ángel
• dc.contributor.author Romaguera Bosch, Dora
• dc.contributor.author Toledo, Estefania
• dc.contributor.author Li, Linzi
• dc.contributor.author Fortuny Fraub, Elena
• dc.contributor.author López, Luis
• dc.contributor.author Ramallal, Raúl
• dc.contributor.author Salas Salvadó, Jordi
• dc.contributor.author Tojal Sierra, Lucas
• dc.contributor.author Castañer, Olga
• dc.contributor.author Alonso, Álvaro
• dc.date.accessioned 2024-05-21T06:24:25Z
• dc.date.available 2024-05-21T06:24:25Z
• dc.date.issued 2023
• dc.description.abstract Evidence supports associations of lifestyle (including diet and physical activity) and weight with cognitive functioning, but the pathways responsible for these associations have not been fully elucidated. Because healthier lifestyles have been associated with better left atrial structure and function, which in turn is associated with better cognitive functioning, we tested the hypothesis that left atrial structure and function is a potential mediator of the association between lifestyle and cognition. We included 476 participants classed as overweight or obese with metabolic syndrome from three centers in Spain. These participants underwent lifestyle assessments and transthoracic echocardiography at baseline and repeated measurements of the Trail Making A test, a measure of executive function, taken at baseline and at the two-year follow-up. We conducted mediation analyses to test if measures of left atrial structure and function mediated associations between adherence to the Mediterranean diet scores, physical activity, and weight at baseline, as well as a two-year change in Trail Making A scores. The analysis did not find an association between these factors and Trail Making A scores, and no indirect effects appeared to be mediated by echocardiographic measurements. The modest sample size in this analysis is a limitation, and larger studies should be conducted to determine potential cardiovascular factors mediating the association between lifestyle and cognition.
• dc.description.sponsorship Research reported in this publication was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under Award Numbers R01HL137338 and K24HL148521 and administrative supplement to promote diversity 3R01HL137338-03S1. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This work was supported by the official Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS), which is co-funded by the European Regional Development Fund (six coordinated FIS projects led by J.S.-S. and JVi, including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158); the Especial Action Project, entitled Implementacion y evaluacion de una intervencion intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to J.S.-S.; the European Research Council Advanced Research Grant 2014–2019, agreement #340918, granted to M.Á.M.-G.; the Recercaixa (number 2013ACUP00194) grant to J.S.-S.; grants from the Consejeria de Salud de la Junta de Andalucia (PI0458/2013, PS0358/2016, PI0137/2018); the PROMETEO/2017/017 grant from the Generalitat Valenciana; and the SEMERGEN grant. None of the funding sources took part in the design, collection, analysis, or interpretation of the data, or the writing of the report, or in the decision to submit the manuscript for publication.
• dc.format.mimetype application/pdf
• dc.identifier.citation Gonzalez Casanova I, Alonso-Gómez ÁM, Romaguera D, Toledo E, Li L, Fortuny E, et al. Lifestyles, left atrial structure and function, and cognitive decline in adults with metabolic syndrome. J Clin Med. 2023 Sep 20;12(18):6066. DOI: 10.3390/jcm12186066
• dc.identifier.doi http://dx.doi.org/10.3390/jcm12186066
• dc.identifier.issn 2077-0383
• dc.identifier.uri http://hdl.handle.net/10230/60198
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof J Clin Med. 2023 Sep 20;12(18):6066
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/340918
• dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Cognitive decline
• dc.subject.keyword Diet
• dc.subject.keyword Left atrium
• dc.subject.keyword Lifestyle
• dc.subject.keyword Physical activity
• dc.subject.keyword Weight
• dc.title Lifestyles, left atrial structure and function, and cognitive decline in adults with metabolic syndrome
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion