The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development

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• dc.contributor.author Mattimoe, Tom
• dc.contributor.author Payer, Bernhard
• dc.date.accessioned 2023-06-26T05:54:31Z
• dc.date.available 2023-06-26T05:54:31Z
• dc.date.issued 2023
• dc.description.abstract In female mammals, the two X chromosomes are subject to epigenetic gene regulation in order to balance X-linked gene dosage with autosomes and in relation to males, which have one X and one Y chromosome. This is achieved by an intricate interplay of several processes; X-chromosome inactivation and reactivation elicit global epigenetic regulation of expression from one X chromosome in a stage-specific manner, whilst the process of X-chromosome upregulation responds to this by fine-tuning transcription levels of the second X. The germline is unique in its function of transmitting both the genetic and epigenetic information from one generation to the next, and remodelling of the X chromosome is one of the key steps in setting the stage for successful development. Here, we provide an overview of the complex dynamics of X-chromosome dosage control during embryonic and germ cell development, and aim to decipher its potential role for normal germline competency.
• dc.format.mimetype application/pdf
• dc.identifier.citation Mattimoe T, Payer B. The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development. Biochem J. 2023 Apr 26;480(8):521-37. DOI: 10.1042/BCJ20220450
• dc.identifier.doi http://dx.doi.org/10.1042/BCJ20220450
• dc.identifier.issn 0264-6021
• dc.identifier.uri http://hdl.handle.net/10230/57322
• dc.language.iso eng
• dc.publisher Portland Press
• dc.relation.ispartof Biochem J. 2023 Apr 26;480(8):521-37
• dc.rights © 2023 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword X chromosome
• dc.subject.keyword Dosage compensation
• dc.subject.keyword Epigenetic reprogramming
• dc.subject.keyword Germ cell development
• dc.title The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion