Dynamic sensitivity and nonlinear interactions influence the system-level evolutionary patterns of phototransduction proteins

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• dc.contributor.author Invergo, Brandon M., 1982-ca
• dc.contributor.author Montanucci, Ludovica, 1978-ca
• dc.contributor.author Bertranpetit, Jaume, 1952-ca
• dc.date.accessioned 2018-04-19T09:22:45Z
• dc.date.available 2018-04-19T09:22:45Z
• dc.date.issued 2015
• dc.description.abstract Determining the influence of complex, molecular-system dynamics on the evolution of proteins is hindered by the significant challenge of quantifying the control exerted by the proteins on system output. We have employed a combination of systems biology and molecular evolution analyses in a first attempt to unravel this relationship. We employed a comprehensive mathematical model of mammalian phototransduction to predict the degree of influence that each protein in the system exerts on the high-level dynamic behaviour. We found that the genes encoding the most dynamically sensitive proteins exhibit relatively relaxed evolutionary constraint. We also investigated the evolutionary and epistatic influences of the many nonlinear interactions between proteins in the system and found several pairs to have coevolved, including those whose interactions are purely dynamical with respect to system output. This evidence points to a key role played by nonlinear system dynamics in influencing patterns of molecular evolution.
• dc.description.sponsorship This work was supported by the Ministerio de Economia y Competitividad, Spain (grant no. BFU2013-43726-P, subprogram BMC) and the María de Maez to Program for Units of Excellence in R&D (MDM-2014-0370); the Departament d'Economia i Coneixement de la Generalitat de Catalunya (Grup de Recerca Consolidat GRC 2014 SGR 866); AGAUR, Generalitat de Catalunya (2011 FI BI 00275 to B.M.I.); and the Spanish Ministry of Science and Innovation (MICINN) (Juan de la Cierva Program to L.M.)
• dc.format.mimetype application/pdf
• dc.identifier.citation Invergo BM, Montanucci L, Bertranpetit J. Dynamic sensitivity and nonlinear interactions influence the system-level evolutionary patterns of phototransduction proteins. Proc Biol Sci. 2015 Dec 7;282(1820):20152215. DOI: 10.1098/rspb.2015.2215
• dc.identifier.doi http://dx.doi.org/10.1098/rspb.2015.2215
• dc.identifier.issn 0962-8452
• dc.identifier.uri http://hdl.handle.net/10230/34402
• dc.language.iso eng
• dc.publisher Royal Societyca
• dc.relation.ispartof Proceedings. Biological sciences. 2015 Dec 7;282(1820):20152215
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2013-43726-P
• dc.rights © The Royal Society. http://dx.doi.org/10.1098/rspb.2015.2215
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.other Evolució molecular
• dc.subject.other Transducció de senyal cel·lular
• dc.subject.other Proteïnes
• dc.title Dynamic sensitivity and nonlinear interactions influence the system-level evolutionary patterns of phototransduction proteinsca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion