A chemocentric approach to the identification of cancer targets
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Flachner, Beátaca
- dc.contributor.author Lorincz, Zsoltca
- dc.contributor.author Carotti, Angeloca
- dc.contributor.author Nicolotti, Orazioca
- dc.contributor.author Kuchipudi, Praveenaca
- dc.contributor.author Kuchipudi, Praveenaca
- dc.contributor.author Remez Vinogradov, Nikita, 1985-ca
- dc.contributor.author Sanz, Ferranca
- dc.contributor.author Tóvári, Józsefca
- dc.contributor.author Szabo, Miklós Jca
- dc.contributor.author Bertók, Bélaca
- dc.contributor.author Cseh, Sándorca
- dc.contributor.author Mestres i López, Jordica
- dc.contributor.author Dormán, Györgyca
- dc.date.accessioned 2015-05-08T07:19:22Z
- dc.date.available 2015-05-08T07:19:22Z
- dc.date.issued 2012ca
- dc.description.abstract A novel chemocentric approach to identifying cancer-relevant targets is introduced. Starting with a large chemical collection, the strategy uses the list of small molecule hits arising from a differential cytotoxicity screening on tumor HCT116 and normal MRC-5 cell lines to identify proteins associated with cancer emerging from a differential virtual target profiling of the most selective compounds detected in both cell lines. It is shown that this smart combination of differential in vitro and in silico screenings (DIVISS) is capable of detecting a list of proteins that are already well accepted cancer drug targets, while complementing it with additional proteins that, targeted selectively or in combination with others, could lead to synergistic benefits for cancer therapeutics. The complete list of 115 proteins identified as being hit uniquely by compounds showing selective antiproliferative effects for tumor cell lines is provideden
- dc.description.sponsorship This work was supported by a grant from the European Comission (CancerGrid, FP-6 LCHC-CT-2006-037559), http://ec.europa.eu/research/fp6/index_en.cfmen
- dc.format.mimetype application/pdfca
- dc.identifier.citation Flachner B, Lorincz Z, Carotti A, Nicolotti O, Kuchipudi P, Remez N et al. A chemocentric approach to the identification of cancer targets. PLoS ONE. 2012;7(4):e35582. DOI: 10.1371/journal.pone.0035582ca
- dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0035582
- dc.identifier.issn 1932-6203ca
- dc.identifier.uri http://hdl.handle.net/10230/23538
- dc.language.iso engca
- dc.publisher Public Library of Science (PLoS)ca
- dc.relation.ispartof PLoS ONE. 2012;7(4):e35582
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP6/37559ca
- dc.rights © 2012 Flachner et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits/nunrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Proteïnesca
- dc.subject.other Molèculesca
- dc.subject.other Genètica -- Regulacióca
- dc.title A chemocentric approach to the identification of cancer targetsen
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca