Early-life and health behaviour influences on lung function in early adulthood

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  • dc.contributor.author Mahmoud, Osama
  • dc.contributor.author Granell, Raquel
  • dc.contributor.author Peralta, Gabriela P.
  • dc.contributor.author García Aymerich, Judith
  • dc.contributor.author Jarvis, Deborah
  • dc.contributor.author Henderson, John
  • dc.contributor.author Sterne, Jonathan
  • dc.date.accessioned 2023-06-19T05:57:56Z
  • dc.date.available 2023-06-19T05:57:56Z
  • dc.date.issued 2023
  • dc.description.abstract Early-life exposures may influence lung function at different stages of the life course. However, the relative importance of characteristics at different stages of infancy and childhood are unclear. To examine the associations and relative importance of early-life events on lung function at age 24 years. We followed 7545 children from the Avon Longitudinal Study of Parents and Children from birth to 24 years. Using previous knowledge, we classified an extensive list of putative risk factors for low lung function, covering sociodemographic, environmental, lifestyle and physiological characteristics, according to timing of exposure: 1) demographic, maternal and child; 2) perinatal; 3) postnatal; 4) early childhood; and 5) adolescence characteristics. Lung function measurements (forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC and forced expiratory flow at 25–75% of FVC) were standardised for sex, age and height. The proportion of the remaining variance explained by each characteristic was calculated. The association and relative importance (RI) of each characteristic for each lung function measure was estimated using linear regression, adjusted for other characteristics in the same and previous categories. Lower maternal perinatal body mass index (BMI), lower birthweight, lower lean mass and higher fat mass in childhood had the largest RI (0.5–7.7%) for decreased FVC. Having no siblings, lower birthweight, lower lean mass and higher fat mass were associated with decreased FEV1 (RI 0.5–4.6%). Higher lean mass and childhood asthma were associated with decreased FEV1/FVC (RI 0.6–0.8%). Maternal perinatal BMI, birthweight, childhood lean and fat mass and early-onset asthma are the factors in infancy and childhood that have the greatest influence on early-adult lung function.
  • dc.description.sponsorship The present analyses are part of the ALEC (Ageing Lungs in European Cohorts) Study (www.alecstudy.org), which has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement number 633212. The content of this article reflects only the authors’ views, and the European Commission is not liable for any use that may be made of the information contained therein. The UK Medical Research Council and Wellcome (grant 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors and J. Sterne will serve as guarantor for the contents of this paper. Funding information for this article has been deposited with the Crossref Funder Registry.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Mahmoud O, Granell R, Peralta GP, Garcia-Aymerich J, Jarvis D, Henderson J, et al. Early-life and health behaviour influences on lung function in early adulthood. Eur Respir J. 2023 Mar 1;61(3):2001316. DOI: 10.1183/13993003.01316-2020
  • dc.identifier.doi http://dx.doi.org/10.1183/13993003.01316-2020
  • dc.identifier.issn 0903-1936
  • dc.identifier.uri http://hdl.handle.net/10230/57210
  • dc.language.iso eng
  • dc.publisher European Respiratory Society
  • dc.relation.ispartof European Respiratory Journal. 2023 Mar 1;61(3):2001316
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/633212
  • dc.rights © The authors 2023. This version is distributed under the terms of the Creative Commons Attribution Licence 4.0.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.other Pulmons
  • dc.subject.other Aparell respiratori
  • dc.subject.other Pulmons -- Malalties
  • dc.title Early-life and health behaviour influences on lung function in early adulthood
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Articles (Departament de Medicina i Ciències de la Vida)
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