International consensus on post-transplantation diabetes mellitus

Sharif, Adnan; Chakkera, Harini; de Vries, Aiko P. J.; Eller, Kathrin; Guthoff, Martina; Haller, Maria C.; Hornum, Mads; Nordheim, Espen; Kautzky-Willer, Alexandra; Krebs, Michael; Kukla, Aleksandra; Kurnikowski, Amelie; Schwaiger, Elisabeth; Montero, Núria; Pascual Santos, Julio; Jenssen, Trond Geir; Porrini, Esteban; Hecking, Manfred

International consensus on post-transplantation diabetes mellitus

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dc.contributor.author Sharif, Adnan
dc.contributor.author Chakkera, Harini
dc.contributor.author de Vries, Aiko P. J.
dc.contributor.author Eller, Kathrin
dc.contributor.author Guthoff, Martina
dc.contributor.author Haller, Maria C.
dc.contributor.author Hornum, Mads
dc.contributor.author Nordheim, Espen
dc.contributor.author Kautzky-Willer, Alexandra
dc.contributor.author Krebs, Michael
dc.contributor.author Kukla, Aleksandra
dc.contributor.author Kurnikowski, Amelie
dc.contributor.author Schwaiger, Elisabeth
dc.contributor.author Montero, Núria
dc.contributor.author Pascual Santos, Julio
dc.contributor.author Jenssen, Trond Geir
dc.contributor.author Porrini, Esteban
dc.contributor.author Hecking, Manfred
dc.date.accessioned 2024-10-30T07:17:08Z
dc.date.available 2024-10-30T07:17:08Z
dc.date.issued 2024
dc.description.abstract Post-transplantation diabetes mellitus (PTDM) remains a leading complication after solid organ transplantation. Previous international PTDM consensus meetings in 2003 and 2013 provided standardized frameworks to reduce heterogeneity in diagnosis, risk stratification and management. However, the last decade has seen significant advancements in our PTDM knowledge complemented by rapidly changing treatment algorithms for management of diabetes in the general population. In view of these developments, and to ensure reduced variation in clinical practice, a 3rd international PTDM Consensus Meeting was planned and held from 6-8 May 2022 in Vienna, Austria involving global delegates with PTDM expertise to update the previous reports. This update includes opinion statements concerning optimal diagnostic tools, recognition of prediabetes (impaired fasting glucose and/or impaired glucose tolerance), new mechanistic insights, immunosuppression modification, evidence-based strategies to prevent PTDM, treatment hierarchy for incorporating novel glucose-lowering agents and suggestions for the future direction of PTDM research to address unmet needs. Due to the paucity of good quality evidence, consensus meeting participants agreed that making GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) recommendations would be flawed. Although kidney-allograft centric, we suggest that these opinion statements can be appraised by the transplantation community for implementation across different solid organ transplant cohorts. Acknowledging the paucity of published literature, this report reflects consensus expert opinion. Attaining evidence is desirable to ensure establishment of optimized care for any solid organ transplant recipient at risk of, or who develops, PTDM as we strive to improve long-term outcomes.
dc.format.mimetype application/pdf
dc.identifier.citation Sharif A, Chakkera H, de Vries APJ, Eller K, Guthoff M, Haller MC, et al. International consensus on post-transplantation diabetes mellitus. Nephrol Dial Transplant. 2024 Feb 28;39(3):531-49. DOI: 10.1093/ndt/gfad258
dc.identifier.doi http://dx.doi.org/10.1093/ndt/gfad258
dc.identifier.issn 0931-0509
dc.identifier.uri http://hdl.handle.net/10230/68398
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof Nephrol Dial Transplant. 2024 Feb 28;39(3):531-49
dc.rights © The Author(s) 2024. Published by Oxford University Press on behalf of the ERA. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword GLP-1 analogues
dc.subject.keyword NODAT
dc.subject.keyword SGLT2 inhibitors
dc.subject.keyword Metabolic syndrome
dc.subject.keyword Post-transplant diabetes mellitus
dc.title International consensus on post-transplantation diabetes mellitus
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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