Causes and pathophysiology of acquired sideroblastic anemia

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• dc.contributor.author Rodríguez-Sevilla, Juan José
• dc.contributor.author Calvo, Xavier
• dc.contributor.author Arenillas Rocha, Leonor
• dc.date.accessioned 2023-02-16T07:09:14Z
• dc.date.available 2023-02-16T07:09:14Z
• dc.date.issued 2022
• dc.description.abstract The sideroblastic anemias are a heterogeneous group of inherited and acquired disorders characterized by anemia and the presence of ring sideroblasts in the bone marrow. Ring sideroblasts are abnormal erythroblasts with iron-loaded mitochondria that are visualized by Prussian blue staining as a perinuclear ring of green-blue granules. The mechanisms that lead to the ring sideroblast formation are heterogeneous, but in all of them, there is an abnormal deposition of iron in the mitochondria of erythroblasts. Congenital sideroblastic anemias include nonsyndromic and syndromic disorders. Acquired sideroblastic anemias include conditions that range from clonal disorders (myeloid neoplasms as myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms with ring sideroblasts) to toxic or metabolic reversible sideroblastic anemia. In the last 30 years, due to the advances in genomic techniques, a deep knowledge of the pathophysiological mechanisms has been accomplished and the bases for possible targeted treatments have been established. The distinction between the different forms of sideroblastic anemia is based on the study of the characteristics of the anemia, age of diagnosis, clinical manifestations, and the performance of laboratory analysis involving genetic testing in many cases. This review focuses on the differential diagnosis of acquired disorders associated with ring sideroblasts.
• dc.format.mimetype application/pdf
• dc.identifier.citation Rodriguez-Sevilla JJ, Calvo X, Arenillas L. Causes and pathophysiology of acquired sideroblastic anemia. Genes (Basel). 2022 Aug 30; 13(9): 1562. DOI: 10.3390/genes13091562
• dc.identifier.doi http://dx.doi.org/10.3390/genes13091562
• dc.identifier.issn 2073-4425
• dc.identifier.uri http://hdl.handle.net/10230/55799
• dc.language.iso eng
• dc.publisher MDPI
• dc.rights Copyright © 2022 by Rodriguez-Sevilla JJ, Calvo X, Arenillas L. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword MDS
• dc.subject.keyword MDS/MPN-RS-T
• dc.subject.keyword SF3B1
• dc.subject.keyword Ring sideroblast
• dc.subject.keyword Sideroblastic anemia
• dc.title Causes and pathophysiology of acquired sideroblastic anemia
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion