Gestational phthalate exposure and lung function during childhood: A prospective population-based study

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  • dc.contributor.author Bosch de Basea i Gómez, Magda, 1982-
  • dc.contributor.author Carsin, Anne-Elie
  • dc.contributor.author Abellan, Alicia
  • dc.contributor.author Cobo, Inés
  • dc.contributor.author Lertxundi, Aitana
  • dc.contributor.author Marin, Natalia
  • dc.contributor.author Soler Blasco, Raquel
  • dc.contributor.author Ibarluzea, Jesús
  • dc.contributor.author Vrijheid, Martine
  • dc.contributor.author Sunyer Deu, Jordi
  • dc.contributor.author Casas Sanahuja, Maribel
  • dc.contributor.author García Aymerich, Judith
  • dc.date.accessioned 2022-11-29T09:13:33Z
  • dc.date.available 2022-11-29T09:13:33Z
  • dc.date.issued 2022
  • dc.description.abstract The potential effect of gestational exposure to phthalates on the lung function levels during childhood is unclear. Therefore, we examined this association at different ages (from 4 to 11 years) and over the whole childhood. Specifically, we measured 9 phthalate metabolites (MEP, MiBP, MnBP, MCMHP, MBzP, MEHHP, MEOHP, MECPP, MEHP) in the urine of 641 gestating women from the INMA study (Spain) and the forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and FEV1/FVC in their offspring at ages 4, 7, 9 and 11. We used linear regression and mixed linear regression with a random intercept for subject to assess the association between phthalates and lung function at each study visit and for the overall childhood, respectively. We also assessed the phthalate metabolites mixture effect on lung function using a Weighted Quantile Sum (WQS) regression. We observed that the phthalate metabolites gestational levels were consistently associated with lower FVC and FEV1 at all ages, both when assessed individually and jointly as a mixture, although most associations were not statistically significant. Of note, a 10% increase in MiBP was related to lower FVC (-0.02 (-0.04, 0)) and FEV1 z-scores (-0.02 (-0.04, -0.01) at age 4. Similar significant reductions in FVC were observed at ages 4 and 7 associated with an increase in MEP and MnBP, respectively, and for FEV1 at age 4 associated with an increase in MBzP. WQS regression consistently identified MBzP as an important contributor to the phthalate mixture effect. We can conclude that the gestational exposure to phthalates was associated with children's lower FVC and FEV1, especially in early childhood, and in a statistically significant manner for MEP, MiBP, MBzP and MnBP. Given the ubiquity of phthalate exposure and its established endocrine disrupting effects in children, our findings support current regulations that limit phthalate exposure.
  • dc.description.sponsorship The INMA study was funded by grants from the European Union (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5–1), and from Spain: Instituto de Salud Carlos III and Ministry of Health (Red INMA G03/176; CB06/02/0041; PI041436, PI081151, PI06/0867, PS09/00090, PI13/02187; FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/1213, PI07/0314, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI12/01890, PI13/1944, PI13/2032, PI14/00891, PI14/1687, PI17/01194, and PI17/00663; MV16/00015; pre-doctoral grant PFIS – FI14/00099, pre-doctoral grant PFIS FIS-FSE: 17/00260, FIS19/1338, MV16/00015, Miguel Servet-FEDER: CP11/0178, and Miguel Servet-FSE: MS13/00054, MSII16/00051, and MS16/00128), CIBERESP; Department of Health of the Basque Government (2005111093 and 2009111069); the Provincial Government of Gipuzkoa (DFG06/004 and DFG08/001); and the Generalitat de Catalunya-CIRIT (1999SGR 00241). ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya. We acknowledge support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX 2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Bosch de Basea M, Carsin AE, Abellan A, Cobo I, Lertxundi A, Marin N, Soler-Blasco R, Ibarluzea J, Vrijheid M, Sunyer J, Casas M, Garcia-Aymerich J. Gestational phthalate exposure and lung function during childhood: A prospective population-based study. Environ Pollut. 2022 Nov 1;312:119833. DOI: 10.1016/j.envpol.2022.119833
  • dc.identifier.doi http://dx.doi.org/10.1016/j.envpol.2022.119833
  • dc.identifier.issn 0269-7491
  • dc.identifier.uri http://hdl.handle.net/10230/55035
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof Environ Pollut. 2022 Nov 1;312:119833
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
  • dc.rights © 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Child health
  • dc.subject.keyword Gestational exposure
  • dc.subject.keyword Lung function
  • dc.subject.keyword Phthalates
  • dc.title Gestational phthalate exposure and lung function during childhood: A prospective population-based study
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Articles (Departament de Medicina i Ciències de la Vida)
Articles (Hospital del Mar Research Institute)
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)