Linked Registries: Connecting Rare Diseases Patient Registries through a Semantic Web Layer

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• dc.contributor.author Sernadela, Pedroca
• dc.contributor.author Queralt Rosinach, Núriaca
• dc.contributor.author Oliveira, José Luisca
• dc.date.accessioned 2018-10-15T07:57:20Z
• dc.date.available 2018-10-15T07:57:20Z
• dc.date.issued 2017
• dc.description.abstract Patient registries are an essential tool to increase current knowledge regarding rare diseases. Understanding these data is a vital step to improve patient treatments and to create the most adequate tools for personalized medicine. However, the growing number of disease-specific patient registries brings also new technical challenges. Usually, these systems are developed as closed data silos, with independent formats and models, lacking comprehensive mechanisms to enable data sharing. To tackle these challenges, we developed a Semantic Web based solution that allows connecting distributed and heterogeneous registries, enabling the federation of knowledge between multiple independent environments. This semantic layer creates a holistic view over a set of anonymised registries, supporting semantic data representation, integrated access, and querying. The implemented system gave us the opportunity to answer challenging questions across disperse rare disease patient registries. The interconnection between those registries using Semantic Web technologies benefits our final solution in a way that we can query single or multiple instances according to our needs. The outcome is a unique semantic layer, connecting miscellaneous registries and delivering a lightweight holistic perspective over the wealth of knowledge stemming from linked rare disease patient registries.
• dc.description.sponsorship The research leading to these results has received funding from the European Community’s Seventh Framework Programme (FP7/2007–2013) under Grant Agreement no.305444—the RD-Connect project. Pedro Sernadela is funded by Fundac¸ao para a Ci ˜ encia e Tecnologia (FCT) under the ˆGrant Agreement SFRH/BD/52484/2014. Lorena Gonzalez- ´Castro is funded by the Xunta de Galicia, including funding from the operative program FSE Galicia 2007–2013, under the Grant Agreement IN809A 19/2015.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Sernadela P, González-Castro L, Carta C, van der Horst E, Lopes P, Kaliyaperumal R. et al. Linked Registries: Connecting Rare Diseases Patient Registries through a Semantic Web Layer. Biomed Res Int. 2017;2017:8327980. DOI: 10.1155/2017/8327980
• dc.identifier.doi http://dx.doi.org/10.1155/2017/8327980
• dc.identifier.issn 2314-6141
• dc.identifier.uri http://hdl.handle.net/10230/35607
• dc.language.iso eng
• dc.publisher Hindawica
• dc.relation.ispartof BioMed Research International. 2017;2017:8327980
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/305444
• dc.rights Copyright © 2017 Pedro Sernadela et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.other Hospitals -- Pacients
• dc.subject.other Històries clíniques -- Automatització
• dc.subject.other Malalties rares
• dc.title Linked Registries: Connecting Rare Diseases Patient Registries through a Semantic Web Layerca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion