Associations between combined urban and lifestyle factors and respiratory health in European children

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• dc.contributor.author Guillien, Alicia
• dc.contributor.author Casas Sanahuja, Maribel
• dc.contributor.author Castro, Montserrat de
• dc.contributor.author Maitre, Léa
• dc.contributor.author Nieuwenhuijsen, Mark J.
• dc.contributor.author Urquiza, José M.
• dc.contributor.author Vrijheid, Martine
• dc.contributor.author Basagaña Flores, Xavier
• dc.contributor.author Siroux, Valérie
• dc.date.accessioned 2024-06-18T06:36:38Z
• dc.date.embargoEnd info:eu-repo/date/embargoEnd/2025-11-29
• dc.date.issued 2024
• dc.description.abstract Introduction: Previous studies identified some environmental and lifestyle factors independently associated with children respiratory health, but few focused on exposure mixture effects. This study aimed at identifying, in pregnancy and in childhood, combined urban and lifestyle environment profiles associated with respiratory health in children. Methods: This study is based on the European Human Early-Life Exposome (HELIX) project, combining six birth cohorts. Associations between profiles of pregnancy (38 exposures) and childhood (84 exposures) urban and lifestyle factors, identified by clustering analysis, and respiratory health were estimated by regression models adjusted for confounders. Results: Among the 1033 included children (mean ± standard-deviation (SD) age: 8.2 ± 1.6 years old, 47% girls) the mean ± SD forced expiratory volume in 1s (FEV1) and forced vital capacity (FVC) were 99 ± 13% and 101 ± 14%, respectively, and 12%, 12% and 24% reported ever-asthma, wheezing and rhinitis, respectively. Four profiles of pregnancy exposures and four profiles of childhood exposures were identified. Compared to the reference childhood exposure profile (low exposures), two exposure profiles were associated with lower levels of FEV1. One profile was characterized by few natural spaces in the surroundings and high exposure to the built environment and road traffic. The second profile was characterized by high exposure to meteorological factors and low levels of all other exposures and was also associated with an increased risk of ever-asthma and wheezing. A pregnancy exposure profile characterized by high exposure levels to all risk factors, but a healthy maternal lifestyle, was associated with a lower risk of wheezing and rhinitis in children, compared to the reference pregnancy profile (low exposures). Conclusion: This comprehensive approach revealed pregnancy and childhood profiles of urban and lifestyle exposures associated with lung function and/or respiratory conditions in children. Our findings highlight the need to pursue the study of combined exposures to improve prevention strategies for multifactorial diseases such as asthma.
• dc.description.sponsorship The research leading to these results has received funding from the European Commission Seventh Framework Programme (FP7/2007–2013) under grant agreement no 308333 – the HELIX project and by the European Commission's Horizon 2020 Framework Program for Research and Innovation, under grant 874583 – the ATHLETE project. This project benefited from a funding from FRM, the Foundation for medical research (EPIMEX project, grant #ENV202004011870).
• dc.embargo.liftdate 2025-11-29
• dc.format.mimetype application/pdf
• dc.identifier.citation Guillien A, Slama R, Andrusaityte S, Casas M, Chatzi L, Castro M, et al. Associations between combined urban and lifestyle factors and respiratory health in European children. Environ Res. 2024 Feb 1;242:117774. DOI: 10.1016/j.envres.2023.117774
• dc.identifier.doi http://dx.doi.org/10.1016/j.envres.2023.117774
• dc.identifier.issn 0013-9351
• dc.identifier.uri http://hdl.handle.net/10230/60501
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Environ Res. 2024 Feb 1;242:117774
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.envres.2023.117774
• dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
• dc.subject.keyword Asthma
• dc.subject.keyword Children
• dc.subject.keyword Environment
• dc.subject.keyword Exposome
• dc.subject.keyword Respiratory health
• dc.title Associations between combined urban and lifestyle factors and respiratory health in European children
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion