Whole Y-chromosome sequences reveal an extremely recent origin of the most common North African paternal lineage E-M183 (M81)

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• dc.contributor.author Solé Morata, Neus, 1988-ca
• dc.contributor.author García-Fernández, Carlaca
• dc.contributor.author Urasin, Vadimca
• dc.contributor.author Bekada, Asmahanca
• dc.contributor.author Fadhlaoui-Zid, Karimaca
• dc.contributor.author Zalloua, Pierre A.ca
• dc.contributor.author Comas, David, 1969-ca
• dc.contributor.author Calafell i Majó, Francescca
• dc.date.accessioned 2017-12-13T08:12:54Z
• dc.date.available 2017-12-13T08:12:54Z
• dc.date.issued 2017
• dc.description.abstract E-M183 (E-M81) is the most frequent paternal lineage in North Africa and thus it must be considered to explore past historical and demographical processes. Here, by using whole Y chromosome sequences from 32 North African individuals, we have identified five new branches within E-M183. The validation of these variants in more than 200 North African samples, from which we also have information of 13 Y-STRs, has revealed a strong resemblance among E-M183 Y-STR haplotypes that pointed to a rapid expansion of this haplogroup. Moreover, for the first time, by using both SNP and STR data, we have provided updated estimates of the times-to-the-most-recent-common-ancestor (TMRCA) for E-M183, which evidenced an extremely recent origin of this haplogroup (2,000-3,000 ya). Our results also showed a lack of population structure within the E-M183 branch, which could be explained by the recent and rapid expansion of this haplogroup. In spite of a reduction in STR heterozygosity towards the West, which would point to an origin in the Near East, ancient DNA evidence together with our TMRCA estimates point to a local origin of E-M183 in NW Africa.
• dc.description.sponsorship Funding was provided by the Agencia Estatal de Investigación and Fondo Europeo de Desarollo Regional (FEDER) (grant CGL2016-75389-P), and by Agència de Gestió d’Ajuts Universitaris i de la Recerca (Generalitat de Catalunya) grant 2014 SGR 866. NS is supported by a Formació de personal Investigador (FI) fellowship from Generalitat de Catalunya (FI_B00685)
• dc.format.mimetype application/pdfca
• dc.identifier.citation Solé-Morata N, García-Fernández C, Urasin V, Bekada A, Fadhlaoui-Zid K, Zalloua P et al. Whole Y-chromosome sequences reveal an extremely recent origin of the most common North African paternal lineage E-M183 (M81). Sci Rep. 2017 Nov 21;7(1):15941. DOI: 10.1038/s41598-017-16271-y
• dc.identifier.doi http://dx.doi.org/10.1038/s41598-017-16271-y
• dc.identifier.issn 2045-2322
• dc.identifier.uri http://hdl.handle.net/10230/33464
• dc.language.iso eng
• dc.publisher Nature Publishing Groupca
• dc.relation.ispartof Scientific Reports. 2017 Nov 21;7(1):15941
• dc.rights © Nature Publishing Group. http://dx.doi.org/10.1038/s41598-017-16271-y. https://creativecommons.org/licenses/by/4.0/
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.other Cromosoma Y
• dc.subject.other Genètica de poblacions humanes -- Àfrica del Nord
• dc.title Whole Y-chromosome sequences reveal an extremely recent origin of the most common North African paternal lineage E-M183 (M81)ca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion