PAKistan Study of prEmature coronary atHerosclerosis in young AdulTs (PAK-SEHAT): a prospective longitudinal study protocol investigating the prevalence, severity and determinants of atherosclerotic cardiovascular disease in the young adult Pakistani population

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• dc.contributor.author Hanif, Bashir
• dc.contributor.author Sheikh, Sana
• dc.contributor.author Peerwani, Ghazal
• dc.contributor.author Cainzos-Achirica, Miguel
• dc.contributor.author Javed, Wajiha
• dc.contributor.author Baqar, Jaffer Bin
• dc.contributor.author Samad, Zainab
• dc.contributor.author Bashir, Faiza
• dc.contributor.author Virani, Salim S.
• dc.contributor.author Nasir, Khurram
• dc.contributor.author Aijaz, Saba
• dc.date.accessioned 2024-10-02T06:15:38Z
• dc.date.available 2024-10-02T06:15:38Z
• dc.date.issued 2023
• dc.description.abstract Introduction: Atherosclerotic cardiovascular disease (ASCVD) is a major cause of morbidity, mortality and health expenditures worldwide. Despite having higher ASCVD in the Pakistani population, data on subclinical coronary atherosclerosis in young Pakistanis remain scarce. The PAKistan Study of prEmature coronary atHerosclerosis in young AdulTs (PAK-SEHAT) aims to assess the prevalence, severity and determinants of subclinical coronary atherosclerosis among Pakistani men (35-60 years) and women (35-65 years) free of clinically symptomatic ASCVD and will assess 5-year rates of ASCVD events. Methods and analysis: PAK-SEHAT is an ongoing prospective cohort study with 2000 participants from all provinces of Pakistan who will be interviewed at the baseline along with phlebotomy, measurement of carotid intima-media thickness (CIMT) and coronary CT angiography (CCTA). Phlebotomy will be repeated at 2.5 years, whereas CIMT and CCTA will be repeated at 5 years. We will report the frequency of maximal coronary stenosis ≥50% and ≥70%, number of coronary vessels with plaque and the number of coronary segments affected per participant on CCTA. We will use Cox proportional hazards regression models to evaluate the association between baseline characteristics and incident ASCVD events during follow-up. These associations will be presented as HRs with 95% CIs. Ethics and dissemination: The study protocol was approved by the Tabba Heart Institute Institutional Review Board (THI/IRB/FQ/22-09-2021/016). All study procedures are consistent with the principles of the Declaration of Helsinki. Findings of the study will be disseminated via peer-reviewed publications and conference presentations. Trial registration number: NCT05156736.
• dc.format.mimetype application/pdf
• dc.identifier.citation Hanif B, Sheikh S, Peerwani G, Cainzos-Achirica M, Javed W, Baqar JB, et al. PAKistan Study of prEmature coronary atHerosclerosis in young AdulTs (PAK-SEHAT): a prospective longitudinal study protocol investigating the prevalence, severity and determinants of atherosclerotic cardiovascular disease in the young adult Pakistani population. BMJ Open. 2023 Nov 19;13(11):e076045. DOI: 10.1136/bmjopen-2023-076045
• dc.identifier.doi http://dx.doi.org/10.1136/bmjopen-2023-076045
• dc.identifier.issn 2044-6055
• dc.identifier.uri http://hdl.handle.net/10230/61291
• dc.language.iso eng
• dc.publisher BMJ Publishing Group
• dc.relation.ispartof BMJ Open. 2023 Nov 19;13(11):e076045
• dc.rights © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Adult cardiology
• dc.subject.keyword Cardiac epidemiology
• dc.subject.keyword Coronary heart disease
• dc.subject.keyword Myocardial infarctio
• dc.title PAKistan Study of prEmature coronary atHerosclerosis in young AdulTs (PAK-SEHAT): a prospective longitudinal study protocol investigating the prevalence, severity and determinants of atherosclerotic cardiovascular disease in the young adult Pakistani population
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion