Incidental findings on brain MRI of cognitively normal first-degree descendants of patients with Alzheimer's disease: a cross-sectional analysis from the ALFA (Alzheimer and Families) project

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• dc.contributor.author Brugulat Serrat, Anna, 1986-ca
• dc.contributor.author Rojas, Santiagoca
• dc.contributor.author Bargallo, Nuriaca
• dc.contributor.author Conesa Bertrán, Gerardoca
• dc.contributor.author Minguillón, Carolinaca
• dc.contributor.author Fauria, Karineca
• dc.contributor.author Gramunt Fombuena, Ninaca
• dc.contributor.author Molinuevo, José Luisca
• dc.contributor.author Domingo Gispert, Juanca
• dc.date.accessioned 2017-07-14T07:22:03Z
• dc.date.available 2017-07-14T07:22:03Z
• dc.date.issued 2017
• dc.description.abstract Objectives: To describe the prevalence of brain MRI incidental findings (IF) in a cohort of cognitively normal first-degree descendants of patients with Alzheimer's disease (AD). Design: Cross-sectional observational study. Setting: All scans were obtained with a 3.0 T scanner. Scans were evaluated by a single neuroradiologist and IF recorded and categorised. The presence of white matter hyperintensities (WMH) was determined with the Fazekas scale and reported as relevant if ≥2. Participants: 575 participants (45–75 years) underwent high-resolution structural brain MRI. Participants were cognitively normal and scored over the respective cut-off values in all the following neuropsychological tests: Mini-Mental State Examination (≥26), Memory Impairment Screen (≥6), Time Orientation Subtest of the Barcelona Test II (≥68), verbal semantic fluency (naming animals ≥12). Clinical Dementia Rating (CDR) had to be 0. Results: 155 participants (27.0%) presented with at least one IF. Relevant WMH were present in 7.8% of the participants, and vascular abnormalities, cyst and brain volume loss in 10.7%, 3.1% and 6.9% of the study volunteers, respectively. Neoplastic brain findings were found in 2.4% of participants and within these, meningiomas were the most common (1.7%) and more frequently found in women. A positive correlation between increasing age and the presence of IF was found. Additionally, brain atrophy greater than that expected by age was significantly more prevalent in participants without a parental history of AD. Conclusions: Brain MRIs of healthy middle-aged participants show a relatively high prevalence of IF even when study participants have been screened for subtle cognitive alterations. Most of our participants are first-degree descendants of patients with AD, and therefore these results are of special relevance for novel imaging studies in the context of AD prevention in cognitively healthy middle-aged participants.
• dc.description.sponsorship The research leading to these results has received funding from ‘la Caixa’ Foundation. Additional funding was obtained from Fondo de Investigación Sanitaria (FIS), Instituto de Salud Carlos III (ISC-III) under grant PI12/00326 and Barcelona city council under agreement #0724/13 and 0940/16. JDG holds a ‘Ramón y Cajal’ fellowship (RYC-2013-13054).
• dc.format.mimetype application/pdfca
• dc.identifier.citation Brugulat-Serrat A, Rojas S, Bargalló N, Conesa G, Minguillón C, Fauria K, Gramunt N, Molinuevo JL, Domingo Gispert J. Incidental findings on brain MRI of cognitively normal first-degree descendants of patients with Alzheimer's disease: a cross-sectional analysis from the ALFA (Alzheimer and Families) project. BMJ Open. 2017; 7(3): e013215. DOI: 10.1136/bmjopen-2016-013215
• dc.identifier.doi http://dx.doi.org/10.1136/bmjopen-2016-013215
• dc.identifier.issn 2044-6055
• dc.identifier.uri http://hdl.handle.net/10230/32543
• dc.language.iso eng
• dc.publisher BMJ Publishing Groupca
• dc.relation.ispartof BMJ Open. 2017; 7(3): e013215
• dc.rights © Brugulat-Serrat A et al. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Alzheimer's disease
• dc.subject.keyword Cerebral MRI
• dc.subject.keyword Healthy
• dc.subject.keyword Incidental finding
• dc.subject.keyword Late middle-aged
• dc.subject.keyword Prevention
• dc.title Incidental findings on brain MRI of cognitively normal first-degree descendants of patients with Alzheimer's disease: a cross-sectional analysis from the ALFA (Alzheimer and Families) projectca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion