How important is EMT for cancer metastasis?

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• dc.contributor.author Celià-Terrassa, Toni
• dc.contributor.author Kang, Yibin
• dc.date.accessioned 2024-11-04T06:49:34Z
• dc.date.available 2024-11-04T06:49:34Z
• dc.date.issued 2024
• dc.description.abstract Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity initially reported in embryonic development, has been increasingly recognized for its importance in cancer progression and metastasis. Despite tremendous progress being made in the past 2 decades in our understanding of the molecular mechanism and functional importance of EMT in cancer, there are several mysteries around EMT that remain unresolved. In this Unsolved Mystery, we focus on the variety of EMT types in metastasis, cooperative and collective EMT behaviors, spatiotemporal characterization of EMT, and strategies of therapeutically targeting EMT. We also highlight new technical advances that will facilitate the efforts to elucidate the unsolved mysteries of EMT in metastasis.
• dc.format.mimetype application/pdf
• dc.identifier.citation Celià-Terrassa T, Kang Y. How important is EMT for cancer metastasis? PLoS Biol. 2024 Feb 7;22(2):e3002487. DOI: 10.1371/journal.pbio.3002487
• dc.identifier.doi http://dx.doi.org/10.1371/journal.pbio.3002487
• dc.identifier.issn 1544-9173
• dc.identifier.uri http://hdl.handle.net/10230/68410
• dc.language.iso eng
• dc.publisher Public Library of Science (PLoS)
• dc.relation.ispartof PLoS Biol. 2024 Feb 7;22(2):e3002487
• dc.rights © 2024 Celià-Terrassa, Kang. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Metastasis
• dc.subject.keyword Breast cancer
• dc.subject.keyword Cancers and neoplasms
• dc.subject.keyword Cancer treatment
• dc.subject.keyword Invasive tumors
• dc.subject.keyword Colorectal cancer
• dc.subject.keyword Metastatic tumors
• dc.subject.keyword Non-small cell lung cancer
• dc.title How important is EMT for cancer metastasis?
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion