Proteomic studies on the management of high-grade serous ovarian cancer patients: a mini-review

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  • dc.contributor.author Bradbury Lobato, Melissa, 1983-
  • dc.contributor.author Borràs, Eva
  • dc.contributor.author Pérez-Benavente, Assumpció
  • dc.contributor.author Gil-Moreno, Antonio
  • dc.contributor.author Santamaria, Anna
  • dc.contributor.author Sabidó Aguadé, Eduard, 1981-
  • dc.date.accessioned 2021-05-28T06:24:29Z
  • dc.date.available 2021-05-28T06:24:29Z
  • dc.date.issued 2021
  • dc.description.abstract High-grade serous ovarian cancer (HGSC) remains the most common and deadly subtype of ovarian cancer. It is characterized by its late diagnosis and frequent relapse despite standardized treatment with cytoreductive surgery and platinum-based chemotherapy. The past decade has seen significant advances in the clinical management and molecular understanding of HGSC following the publication of the Cancer Genome Atlas (TCGA) researchers and the introduction of targeted therapies with anti-angiogenic drugs and poly(ADP-ribose) polymerase inhibitors in specific subgroups of patients. We provide a comprehensive review of HGSC, focusing on the most important molecular advances aimed at providing a better understanding of the disease and its response to treatment. We emphasize the role that proteomic technologies are now playing in these two aspects of the disease, through the identification of proteins and their post-translational modifications in ovarian cancer tumors. Finally, we highlight how the integration of proteomics with genomics, exemplified by the work performed by the Clinical Proteomic Tumor Analysis Consortium (CPTAC), can guide the development of new biomarkers and therapeutic targets.
  • dc.description.sponsorship This work was supported by the PhD4MD collaborative research program between the Vall d’Hebron Research Institute (VHIR) and the Centre for Genomic Regulation (CRG). The CRG/UPF Proteomics Unit is part of the Spanish Infrastructure for Omics Technologies (ICTS OmicsTech) and it is a member of the ProteoRed PRB3 consortium which is supported by grant PT17/0019 of the PE I + D + i 2013–2016 from the Instituto de Salud Carlos III (ISCIII) and ERDF. We acknowledge support from the Spanish Ministry of Science and Innovation (CTQ2016-80364-P) and “Centro de Excelencia Severo Ochoa 2013–2017”, SEV-2012-0208; the “Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement de la Generalitat de Catalunya” (2017SGR595 and 2017SGR1661), from the Instituto de Salud Carlos III (PI15/02238, PI18/01017, CPII18/00027) and from the Ministerio de Economia y Competitividad y Fondos FEDER (RTC-2015-3821). We also acknowledge the support of the Spanish Ministry of Science and Innovation to the EMBL partnership, the Centro de Excelencia Severo Ochoa and the CERCA Programme/Generalitat de Catalunya
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Bradbury M, Borràs E, Pérez-Benavente A, Gil-Moreno A, Santamaria A, Sabido E. Proteomic studies on the management of high-grade serous ovarian cancer patients: a mini-review. Cancers (Basel). 2021 Apr 25;13(9):2067. DOI: 10.3390/cancers13092067
  • dc.identifier.doi http://dx.doi.org/10.3390/cancers13092067
  • dc.identifier.issn 2072-6694
  • dc.identifier.uri http://hdl.handle.net/10230/47675
  • dc.language.iso eng
  • dc.publisher MDPI
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/CTQ2016-80364-P
  • dc.rights © 2021 by Melissa Bradbury et al. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri https://creativecommons.org/licenses/by/4.0/
  • dc.subject.other Ovaris -- Càncer
  • dc.subject.other Proteòmica
  • dc.title Proteomic studies on the management of high-grade serous ovarian cancer patients: a mini-review
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Center for Genomic Regulation (CRG))
Articles (Departament de Medicina i Ciències de la Vida)