Spatiotemporal control of forkhead binding to DNA regulates the meiotic gene expression program

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• dc.contributor.author Alves-Rodrigues, Isabelca
• dc.contributor.author Ferreira, Pedro G.ca
• dc.contributor.author Moldón Vara, Albertoca
• dc.contributor.author Vivancos Prellezo, Anaca
• dc.contributor.author Hidalgo Hernando, Elenaca
• dc.contributor.author Guigó Serra, Rodericca
• dc.contributor.author Ayté del Olmo, Joséca
• dc.date.accessioned 2016-01-22T18:35:22Z
• dc.date.available 2016-01-22T18:35:22Z
• dc.date.issued 2016
• dc.description.abstract Meiosis is a differentiated program of the cell cycle that is characterized by high levels of recombination followed by two nuclear divisions. In fission yeast, the genetic program during meiosis is regulated at multiple levels, including transcription, mRNA stabilization, and splicing. Mei4 is a forkhead transcription factor that controls the expression of mid-meiotic genes. Here, we describe that Fkh2, another forkhead transcription factor that is essential for mitotic cell-cycle progression, also plays a pivotal role in the control of meiosis. Fkh2 binding preexists in most Mei4-dependent genes, inhibiting their expression. During meiosis, Fkh2 is phosphorylated in a CDK/Cig2-dependent manner, decreasing its affinity for DNA, which creates a window of opportunity for Mei4 binding to its target genes. We propose that Fkh2 serves as a placeholder until the later appearance of Mei4 with a higher affinity for DNA that induces the expression of a subset of meiotic genes.ca
• dc.description.sponsorship This work was supported by grants from the Spanish Ministerio de Economia y Competitividad (MINECO) (grants BFU2012-31939 and BFU2015-66347), PLAN E, and Feder. E.H. is a recipient of an ICREA Academia Award (Generalitat de Catalunya).
• dc.format.mimetype application/pdfca
• dc.identifier.citation Alves-Rodrigues I, Ferreira PG, Moldón A, Vivancos AP, Hidalgo E, Guigó R et al. Spatiotemporal control of forkhead binding to DNA regulates the meiotic gene expression program. Cell Reports. 2016;14(4):885-95. DOI: 10.1016/j.celrep.2015.12.074ca
• dc.identifier.doi http://dx.doi.org/10.1016/j.celrep.2015.12.074
• dc.identifier.issn 2211-1247
• dc.identifier.uri http://hdl.handle.net/10230/25642
• dc.language.iso engca
• dc.publisher Elsevierca
• dc.relation.ispartof Cell Reports. 2016;14(4):885-95
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-31939
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2015-66347
• dc.rights © 2016 The Authors. Published by Elsevier Ltd. Open access under CC BY-NC-ND licenseca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ca
• dc.subject.other ADNca
• dc.subject.other Expressió gènicaca
• dc.title Spatiotemporal control of forkhead binding to DNA regulates the meiotic gene expression programca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca