Association of chronic inflammation and perceived stress with abnormal functional connectivity in brain areas involved with interoception in hepatitis C patients

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• dc.contributor.author Oriolo, Giovanni
• dc.contributor.author Blanco Hinojo, Laura, 1981-
• dc.contributor.author Navinés, Ricard
• dc.contributor.author Mariño, Zoe
• dc.contributor.author Martín-Hernández, David
• dc.contributor.author Cavero, Myriam
• dc.contributor.author Gimenez, Dolors
• dc.contributor.author Caso, Javier
• dc.contributor.author Capuron, Lucile
• dc.contributor.author Forns, Xavier
• dc.contributor.author Pujol Martí, Jesús, 1981-
• dc.contributor.author Martín Santos, Rocío
• dc.date.accessioned 2019-11-20T08:45:02Z
• dc.date.issued 2019
• dc.description.abstract BACKGROUND: Sickness behavioral changes elicited by inflammation may become prolonged and dysfunctional in patients with chronic disease, such as chronic hepatitis C (CHC). Neuroimaging studies show that the basal ganglia and insula are sensitive to systemic inflammation. AIM: To elucidate the clinical and neurobiological aspects of prolonged illnesses in patients with CHC. METHODS: Thirty-five CHC patients not treated with interferon-α or other antiviral therapy, and 30 control subjects matched for age and sex, were evaluated for perceived stress (perceived stress scale; PSS), depression (PHQ-9), fatigue and irritability through a visual analog scale (VAS), as well as serum levels of interleukin-6 (IL-6), prostaglandin E2 (PGE2) and oxidative stress markers. Functional MRI was performed, measuring resting-state functional connectivity using a region-of-interest (seed)-based approach focusing on the bilateral insula, subgenual anterior cingulate cortex and bilateral putamen. Between-group differences in functional connectivity patterns were assessed with two-sample t-tests, while the associations between symptoms, inflammatory markers and functional connectivity patterns were analyzed with multiple regression analyses. RESULTS: CHC patients had higher PSS, PHQ-9 and VAS scores for fatigue and irritability, as well as increased IL-6 levels, PGE2 concentrations and antioxidant system activation compared to controls. PSS scores positively correlated with functional connectivity between the right anterior insula and right putamen, whereas PHQ-9 scores correlated with functional connectivity between most of the seeds and the right anterior insula. PGE2 (positively) and IL-6 (negatively) correlated with functional connectivity between the right anterior insula and right caudate nucleus and between the right ventral putamen and right putamen/globus pallidus. PGE2 and PSS scores accounted for 46% of the variance in functional connectivity between the anterior insula and putamen. CONCLUSIONS: CHC patients exhibited increased perceived stress and depressive symptoms, which were associated with changes in inflammatory marker levels and in functional connectivity between the insula and putamen, areas involved in interoceptive integration, emotional awareness, and orientation of motivational state.
• dc.format.mimetype application/pdf
• dc.identifier.citation Oriolo G, Blanco-Hinojo L, Navines R, Mariño Z, Martín-Hernández D, Cavero M. et al. Association of chronic inflammation and perceived stress with abnormal functional connectivity in brain areas involved with interoception in hepatitis C patients. Brain Behav Immun. 2019 Aug;80:204-218. DOI 10.1016/j.bbi.2019.03.008
• dc.identifier.doi http://dx.doi.org/10.1016/j.bbi.2019.03.008
• dc.identifier.issn 0889-1591
• dc.identifier.uri http://hdl.handle.net/10230/42898
• dc.language.iso eng
• dc.publisher Elsevier
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.bbi.2019.03.008
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Basal ganglia
• dc.subject.keyword Depression
• dc.subject.keyword Functional connectivity
• dc.subject.keyword Hepatitis C virus
• dc.subject.keyword IL-6
• dc.subject.keyword Inflammation
• dc.subject.keyword Insula
• dc.subject.keyword Interoception
• dc.subject.keyword Perceived stress
• dc.subject.keyword Prostaglandin E(2)
• dc.subject.keyword Sickness behavior
• dc.title Association of chronic inflammation and perceived stress with abnormal functional connectivity in brain areas involved with interoception in hepatitis C patients
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion