IHI VICT3R: Developing and implementing virtual control groups to reduce animal use in toxicology research
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- dc.contributor.author Steger-Hartmann, Thomas
- dc.contributor.author Sanz, Ferran
- dc.contributor.author Bringezu, Frank
- dc.contributor.author Soininen, Inari
- dc.date.accessioned 2024-12-18T13:49:53Z
- dc.date.available 2024-12-18T13:49:53Z
- dc.date.issued 2024
- dc.description.abstract The virtual control group (VCG) concept was originally developed in the IMI2 project eTRANSAFE, using data of control animals which pharmaceutical companies have accrued over decades from animal toxicity studies. This control data could be repurposed to create virtual control animals to reduce or replace concurrent controls in animal studies. Initial work demonstrated the general feasibility of the VCG concept, but implementation requires significant further collaborative efforts. The new Innovative Health Initiative (IHI) project VICT3R aims to address these challenges and to obtain regulatory acceptance for the VCG concept. To achieve these goals, VICT3R will build a database comprising high-quality, standardized, and duly annotated control animal data from past and forthcoming toxicity studies. The VICT3R project will create workflows and computational tools to generate adequate VCGs based on statistical and artificial intelligence (AI) approaches. The validity, reproducibility, and robustness of the resulting VCGs will be assessed by comparing the performance of their use with that of real control groups.
- dc.identifier.citation Steger-Hartmann T, Sanz F, Bringezu F, Soininen I. IHI VICT3R: Developing and implementing virtual control groups to reduce animal use in toxicology research. Toxicol Pathol. 2024 Dec 12:1926233241303906. DOI: 10.1177/01926233241303906
- dc.identifier.doi http://dx.doi.org/10.1177/01926233241303906
- dc.identifier.issn 0192-6233
- dc.identifier.uri http://hdl.handle.net/10230/68985
- dc.language.iso eng
- dc.publisher Sage Publications
- dc.rights Steger-Hartmann T, Sanz F, Bringezu F, Soininen I. IHI VICT3R: Developing and implementing virtual control groups to reduce animal use in toxicology research. Toxicol Pathol. 2024 Dec 12:1926233241303906. Copyright © The Author(s) 2024. DOI: 10.1177/01926233241303906
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword 3R
- dc.subject.keyword Historical control animal data
- dc.subject.keyword Virtual control groups
- dc.title IHI VICT3R: Developing and implementing virtual control groups to reduce animal use in toxicology research
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion