Age-associated inflammation inhibits epidermal stem cell function
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- dc.contributor.author Doles, Jasonca
- dc.contributor.author Storer, Mekayla, 1981-ca
- dc.contributor.author Cozzuto, Lucaca
- dc.contributor.author Roma, Guglielmoca
- dc.contributor.author Keyes, William M., 1973-ca
- dc.date.accessioned 2015-04-30T07:23:57Z
- dc.date.available 2015-04-30T07:23:57Z
- dc.date.issued 2012ca
- dc.description.abstract Altered stem cell homeostasis is linked to organismal aging. However, the mechanisms involved remain poorly understood. Here we report novel alterations in hair follicle stem cells during skin aging, including increased numbers, decreased function, and an inability to tolerate stress. Performing high-throughput RNA sequencing on aging stem cells, cytokine arrays, and functional assays, we identify an age-associated imbalance in epidermal Jak-Stat signaling that inhibits stem cell function. Collectively, this study reveals a role for the aging epidermis in the disruption of cytokine and stem cell homeostasis, suggesting that stem cell decline during aging may be part of broader tumor-suppressive mechanisms.
- dc.description.sponsorship J.D. is supported by an EMBO long-term fellowship, and M.A.S. is funded by a La Caixa bank studentship. This work was funded in part by a Plan Nacional grant to W.M.K. from the Spanish/nMinistry for Science and Innovation (SAF2010-18829)
- dc.format.mimetype application/pdfca
- dc.identifier.citation Doles J, Storer M, Cozzuto L, Roma G, Keyes WM. Age-associated inflammation/ninhibits epidermal stem cell function. Genes Dev. 2012 Oct 1;26(19):2144-53. DOI: 10.1101/gad.192294.112ca
- dc.identifier.doi http://dx.doi.org/10.1101/gad.192294.112
- dc.identifier.issn 0890-9369ca
- dc.identifier.uri http://hdl.handle.net/10230/23506
- dc.language.iso engca
- dc.publisher Cold Spring Harbor Laboratory Press (CSHL Press)ca
- dc.relation.ispartof Genes & Development. 2012 Oct 1;26(19):2144-53
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2010-18829
- dc.rights Copyright © 2012, Genes and Development by Cold Spring Harbor Laboratory Press. Published version available at http://genesdev.cshlp.org/ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Envelliment
- dc.subject.other Epidermis -- Citologia
- dc.subject.other Inflamació
- dc.subject.other Cèl·lules mare -- Citologia
- dc.title Age-associated inflammation inhibits epidermal stem cell functionca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca