Carbohydrate quality, fecal microbiota and cardiometabolic health in older adults: a cohort study

Atzeni, Alessandro; Nishi, Stephanie; Babio, Nancy; Belzer, Clara; Konstanti, Prokopis; Vioque, Jesus; Corella, Dolores; Castañer, Olga; Vidal, Josep; Moreno-Indias, Isabel; Torres-Collado, Laura; Asensio, Eva María; Fitó Colomer, Montserrat; Gómez Pérez, Ana María; Arias, Alejandro; Ruiz-Canela, Miguel; Hu, Frank B.; Tinahones Madueño, Francisco José; Salas Salvadó, Jordi

doi:http://dx.doi.org/10.1080/19490976.2023.2246185

Carbohydrate quality, fecal microbiota and cardiometabolic health in older adults: a cohort study

Citation

Atzeni A, Nishi SK, Babio N, Belzer C, Konstanti P, Vioque J, et al. Carbohydrate quality, fecal microbiota and cardiometabolic health in older adults: a cohort study. Gut Microbes. 2023 Dec;15(2):2246185. DOI: 10.1080/19490976.2023.2246185

Abstract

The impact of carbohydrate quality, measured by the carbohydrate quality index (CQI), on gut microbiota and health has been scarcely investigated. The aim of this study was to cross-sectionally and longitudinally explore the relationships between CQI, fecal microbiota, and cardiometabolic risk factors in an elderly Mediterranean population at high cardiovascular risk. At baseline and 1-year, CQI was assessed from food frequency questionnaires data, cardiometabolic risk factors were measured, and fecal microbiota profiled from 16S sequencing. Multivariable-adjusted linear regression models were fitted to assess the associations between tertiles of baseline CQI, fecal microbiota, and cardiometabolic risk factors at baseline, and between tertiles of 1-year change in CQI, 1-year change in fecal microbiota and cardiometabolic risk factors. Cross-sectionally, higher CQI was positively associated with Shannon alpha diversity index, and abundance of genera Faecalibacterium and Christensenellaceae R7 group, and negatively associated with the abundance of Odoribacter, and uncultured Rhodospirillales genera. Some of these genera were associated with higher glycated hemoglobin and lower body mass index. In addition, we observed a positive association between CQI, and some pathways related with the metabolism of butyrate precursors and plants-origin molecules. Longitudinally, 1-year improvement in CQI was associated with a concurrent increase in the abundance of genera Butyrivibrio. Increased abundance of this genera was associated with 1-year improvement in insulin status. These observations suggest that a better quality of carbohydrate intake is associated with improved metabolic health, and this improvement could be modulated by greater alpha diversity and abundance of specific genera linked to beneficial metabolic outcomes.