Altered brain-derived neurotrophic factor blood levels and gene variability are associated with anorexia and bulimia

Mercader Bigas, Josep Maria; Ribasés, Marta; Gratacós Mayora, Mònica; González Ruiz, Juan Ramón; Bayés, Mònica; Cid Ibeas, Rafael de; Badía, Anna; Fernández Aranda, Fernando; Estivill, Xavier, 1955-

Altered brain-derived neurotrophic factor blood levels and gene variability are associated with anorexia and bulimia

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dc.contributor.author Mercader Bigas, Josep Mariaca
dc.contributor.author Ribasés, Martaca
dc.contributor.author Gratacós Mayora, Mònicaca
dc.contributor.author González Ruiz, Juan Ramónca
dc.contributor.author Bayés, Mònicaca
dc.contributor.author Cid Ibeas, Rafael deca
dc.contributor.author Badía, Annaca
dc.contributor.author Fernández Aranda, Fernandoca
dc.contributor.author Estivill, Xavier, 1955-ca
dc.date.accessioned 2012-05-31T10:32:57Z
dc.date.available 2012-05-31T10:32:57Z
dc.date.issued 2007ca
dc.description.abstract Murine models and association studies in eating disorder (ED) patients have shown a role for the brain-derived neurotrophic factor (BDNF) in eating behavior. Some studies have shown association of BDNF -270C/T single-nucleotide polymorphism (SNP) with bulimia nervosa (BN), while BDNF Val66Met variant has been shown to be associated with both BN and anorexia nervosa (AN). To further test the role of this neurotrophin in humans, we screened 36 SNPs in the BDNF gene and tested for their association with ED and plasma BDNF levels as a quantitative trait. We performed a family-based association study in 106 ED nuclear families and analyzed BDNF blood levels in 110 ED patients and in 50 sib pairs discordant for ED. The rs7124442T/rs11030102C/rs11030119G haplotype was found associated with high BDNF levels (mean BDNF TCG haplotype carriers = 43.6 ng/ml vs. mean others 23.0 ng/ml, P = 0.016) and BN (Z = 2.64; P recessive = 0.008), and the rs7934165A/270T haplotype was associated with AN (Z =-2.64; P additive = 0.008). The comparison of BDNF levels in 50 ED discordant sib pairs showed elevated plasma BDNF levels for the ED group (mean controls = 41.0 vs. mean ED = 52.7; P = 0.004). Our data strongly suggest that altered BDNF levels modulated by BDNF gene variability are associated with the susceptibility to ED, providing physiological evidence that BDNF plays a role in the development of AN and BN, and strongly arguing for its involvement in eating behavior and body weight regulation.
dc.format.mimetype application/pdfca
dc.identifier.citation Mercader JM, Ribasés M, Gratacòs M, González JR, Bayés M, de Cid R et al. Altered brain-derived neurotrophic factor blood levels and gene variability are associated with anorexia and bulimia. Genes Brain Behav. 2007;6(8):706-16. DOI: 10.1111/j.1601-183X.2007.00301.xca
dc.identifier.doi http://dx.doi.org/10.1111/j.1601-183X.2007.00301.x
dc.identifier.issn 1601-1848ca
dc.identifier.uri http://hdl.handle.net/10230/16495
dc.language.iso engca
dc.publisher John Wiley & Sonsca
dc.relation.ispartof Genes, Brain and Behavior. 2007;6(8):706-16
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.subject.keyword Anorexia
dc.subject.keyword BDNF
dc.subject.keyword Bulimia
dc.subject.keyword Eating disorders
dc.subject.keyword Family-based association study
dc.subject.keyword Plasma levels
dc.subject.other Trastorns de la conducta alimentària -- Aspectes genètics
dc.subject.other Anorèxia nerviosa
dc.subject.other Bulímia
dc.title Altered brain-derived neurotrophic factor blood levels and gene variability are associated with anorexia and bulimiaca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/submittedVersion

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