Cystatin C estimated glomerular filtration rate to assess renal function in early stages of autosomal dominant polycystic kidney disease

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• dc.contributor.author Sans Atxer, Laiaca
• dc.contributor.author Radosevic, Aleksandar, 1974-ca
• dc.contributor.author Quintian, Claudiaca
• dc.contributor.author Montañé, Rosarioca
• dc.contributor.author Gràcia, Silviaca
• dc.contributor.author Vilaplana, Carlesca
• dc.contributor.author Mojal, Sergioca
• dc.contributor.author Ballarin, José A.ca
• dc.contributor.author Fernández-Llama, Patriciaca
• dc.contributor.author Torra, Roserca
• dc.contributor.author Pascual Santos, Julioca
• dc.date.accessioned 2018-02-26T08:11:39Z
• dc.date.available 2018-02-26T08:11:39Z
• dc.date.issued 2017
• dc.description.abstract BACKGROUND/AIMS: Height-adjusted total kidney volume (htTKV) is the best marker of disease progression in early autosomal dominant polycystic kidney disease (ADPKD) when renal function still remains normal. The usefulness of cystatin-C as a biomarker to assess renal function according to renal volume has not been studied in ADPKD patients. METHODS: Observational and cross-sectional study of 62 ADPKD patients. htTKV, creatinine and cystatin-C estimated glomerular filtration rate (eGFR) were determined. Correlations between htTKV and eGFR were studied. A control group was used to determine the association between renal function differences and htTKV. RESULTS: htTKV significantly correlated with cystatin-C-eGFR (r = -0.384, p = 0.002) but not with creatinine-eGFR (r = -0.225, p = 0.078). With htTKV stratified into tertiles, a significant difference of cystatin-C-eGFR but not in creatinine-eGFR was detected in the third tertile when compared with the first tertile group (110.0±22.2 vs 121.3±7.2; p = 0.023 and 101.8±17.2 vs 106.9±15.1; p = 0.327 respectively). When cystatin-C-eGFR of the controls was used as the reference, htTKV above 605 ml/m identified with a 75% sensitivity and 84.9% specificity those patients with a significant worse kidney function. However, this cut-off value could not be identified using creatinine-eGFR. CONCLUSIONS: Cystatin-C-eGFR but not creatinine-eGFR correlated with htTKV in ADPKD patients in early stages of the disease. Differences in cystatin-C-eGFR but not in creatinine-eGFR have been identified through htTKV tertiles. A htTKV above 605 ml/m is associated with a worse renal function only if cystatin-C-eGFR is used. Cystatin-C-eGFR should be studied in prospective studies of early stages of ADPKD to determine its usefulness as an early marker of disease progression.
• dc.format.mimetype application/pdf
• dc.identifier.citation Sans L, Radosevic A, Quintian C, Montañés R, Gràcia S, Vilaplana C. et al. Cystatin C estimated glomerular filtration rate to assess renal function in early stages of autosomal dominant polycystic kidney disease. PLoS One. 2017 Mar 27;12(3):e0174583. DOI: 10.1371/journal.pone.0174583
• dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0174583
• dc.identifier.issn 1932-6203
• dc.identifier.uri http://hdl.handle.net/10230/33997
• dc.language.iso eng
• dc.publisher Public Library of Science (PLoS)ca
• dc.relation.ispartof PLoS One. 2017 Mar 27;12(3):e0174583
• dc.rights © 2017 Sans et al. This is an open access article distributed under the terms of the https://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.other Ronyons -- Malalties
• dc.title Cystatin C estimated glomerular filtration rate to assess renal function in early stages of autosomal dominant polycystic kidney diseaseca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion