Could pulmonary low-dose radiation therapy be an alternative treatment for patients with COVID-19 pneumonia? Preliminary results of a multicenter SEOR-GICOR nonrandomized prospective trial (IPACOVID trial)

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  • dc.contributor.author Arenas Prat, Meritxell
  • dc.contributor.author Algara López, Manuel-Ignacio
  • dc.contributor.author Febrer, Gabriel de
  • dc.contributor.author Rubio, Carmen
  • dc.contributor.author Sanz, Xavier
  • dc.contributor.author De La Casa-Lillo, Miguel Ángel
  • dc.contributor.author Vasco, Carlos
  • dc.contributor.author Marín, Jesús
  • dc.contributor.author Fernández-Letón, Pedro
  • dc.contributor.author Villar García, Judit
  • dc.contributor.author Torres-Royo, Laura
  • dc.contributor.author Villares, Paula
  • dc.contributor.author Membrive, Ismael
  • dc.contributor.author Acosta, Juan Carlos
  • dc.contributor.author López-Cano, Manuel
  • dc.contributor.author Araguas, Pablo
  • dc.contributor.author Quera Jordana, Jaume
  • dc.contributor.author Rodríguez-Tomás, F.
  • dc.contributor.author Montero, Ángel
  • dc.date.accessioned 2022-06-29T06:10:31Z
  • dc.date.available 2022-06-29T06:10:31Z
  • dc.date.issued 2021
  • dc.description.abstract Purpose: To evaluate the efficacy and safety of lung low-dose radiation therapy (LD-RT) for pneumonia in patients with coronavirus disease 2019 (COVID-19). Materials and methods: Inclusion criteria comprised patients with COVID-19-related moderate-severe pneumonia warranting hospitalization with supplemental O2 and not candidates for admission to the intensive care unit because of comorbidities or general status. All patients received single lung dose of 0.5 Gy. Respiratory and systemic inflammatory parameters were evaluated before irradiation, at 24 h and 1 week after LD-RT. Primary endpoint was increased in the ratio of arterial oxygen partial pressure (PaO2) or the pulse oximetry saturation (SpO2) to fractional inspired oxygen (FiO2) ratio of at least 20% at 24 h with respect to the preirradiation value. Results: Between June and November 2020, 36 patients with COVID-19 pneumonia and a mean age of 84 years were enrolled. Seventeen were women and 19 were men and all of them had comorbidities. All patients had bilateral pulmonary infiltrates on chest X‑ray. All patients received dexamethasone treatment. Mean SpO2 pretreatment value was 94.28% and the SpO2/FiO2 ratio varied from 255 mm Hg to 283 mm Hg at 24 h and to 381 mm Hg at 1 week, respectively. In those who survived (23/36, 64%), a significant improvement was observed in the percentage of lung involvement in the CT scan at 1 week after LD-RT. No adverse effects related to radiation treatment have been reported. Conclusions: LD-RT appears to be a feasible and safe option in a population with COVID-19 bilateral interstitial pneumonia in the presence of significant comorbidities.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Arenas M, Algara M, De Febrer G, Rubio C, Sanz X, de la Casa MA, Vasco C, Marín J, Fernández-Letón P, Villar J, Torres-Royo L, Villares P, Membrive I, Acosta J, López-Cano M, Araguas P, Quera J, Rodríguez-Tomás F, Montero A. Could pulmonary low-dose radiation therapy be an alternative treatment for patients with COVID-19 pneumonia? Preliminary results of a multicenter SEOR-GICOR nonrandomized prospective trial (IPACOVID trial). Strahlenther Onkol. 2021 Nov;197(11):1010-20. DOI: 10.1007/s00066-021-01803-3
  • dc.identifier.doi http://dx.doi.org/10.1007/s00066-021-01803-3
  • dc.identifier.issn 0179-7158
  • dc.identifier.uri http://hdl.handle.net/10230/53630
  • dc.language.iso eng
  • dc.publisher Springer
  • dc.relation.ispartof Strahlenther Onkol. 2021 Nov;197(11):1010-20
  • dc.rights © The Author(s) 2021, corrected publication 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Anti-inflammatory effects
  • dc.subject.keyword COVID-19 pneumonia
  • dc.subject.keyword Low-dose radiation therapy
  • dc.subject.keyword Lung irradiation
  • dc.subject.keyword Treatment outcome
  • dc.title Could pulmonary low-dose radiation therapy be an alternative treatment for patients with COVID-19 pneumonia? Preliminary results of a multicenter SEOR-GICOR nonrandomized prospective trial (IPACOVID trial)
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion