Clinical, microbiological and treatment characteristics of severe postoperative respiratory infections: An observational cohort study

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• dc.contributor.author Benítez-Cano, Adela
• dc.contributor.author Bermejo Martínez, Silvia
• dc.contributor.author Luque, Sonia
• dc.contributor.author Sorlí, Luisa
• dc.contributor.author Carazo Cordobés, Jesús
• dc.contributor.author Zaragoza, Irene
• dc.contributor.author Ramos, Isabel
• dc.contributor.author Vallès, Jordi
• dc.contributor.author Horcajada Gallego, Juan Pablo
• dc.contributor.author Adalia Bartolomé, Ramón
• dc.date.accessioned 2024-03-22T08:23:03Z
• dc.date.available 2024-03-22T08:23:03Z
• dc.date.issued 2023
• dc.description.abstract Respiratory infections are frequent and life-threatening complications of surgery. This study aimed to evaluate the clinical, microbiological and treatment characteristics of severe postoperative pneumonia (POP) and tracheobronchitis (POT) in a large series of patients. This single-center, prospective observational cohort study included patients with POP or POT requiring intensive care unit admission in the past 10 years. We recorded demographic, clinical, microbiological and therapeutic data. A total of 207 patients were included, and 152 (73%) were men. The mean (SD) age was 70 (13) years and the mean (SD) ARISCAT score was 46 (19). Ventilator-associated pneumonia was reported in 21 patients (10%), hospital-acquired pneumonia was reported in 132 (64%) and tracheobronchitis was reported in 54 (26%). The mean (SD) number of days from surgery to POP/POT diagnosis was 6 (4). The mean (SD) SOFA score was 5 (3). Respiratory microbiological sampling was performed in 201 patients (97%). A total of 177 organisms were cultured in 130 (63%) patients, with a high proportion of Gram-negative and multi-drug resistant (MDR) bacteria (20%). The most common empirical antibiotic therapy was a triple-drug regimen covering MDR Gram-negative bacteria and MRSA. In conclusion, surgical patients are a high-risk population with a high proportion of early onset severe POP/POT and nosocomial bacteria isolation.
• dc.format.mimetype application/pdf
• dc.identifier.citation Benítez-Cano A, Bermejo S, Luque S, Sorlí L, Carazo J, Zaragoza I, et al. Clinical, microbiological and treatment characteristics of severe postoperative respiratory infections: An observational cohort study. J Pers Med. 2023 Oct 11;13(10):1482. DOI: 10.3390/jpm13101482
• dc.identifier.doi http://dx.doi.org/10.3390/jpm13101482
• dc.identifier.issn 2075-4426
• dc.identifier.uri http://hdl.handle.net/10230/59522
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof J Pers Med. 2023 Oct 11;13(10):1482
• dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Critically ill
• dc.subject.keyword Pneumonia
• dc.subject.keyword Postoperative
• dc.subject.keyword Severe respiratory infection
• dc.subject.keyword Tracheobronchitis
• dc.title Clinical, microbiological and treatment characteristics of severe postoperative respiratory infections: An observational cohort study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion