Proteostatic and metabolic control of stemness

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author García Forero, Carlos
• dc.contributor.author Sousa-Victor, Pedro
• dc.contributor.author Muñoz Cánoves, Pura, 1962-
• dc.date.accessioned 2019-03-15T13:11:29Z
• dc.date.available 2019-03-15T13:11:29Z
• dc.date.issued 2017
• dc.description.abstract Adult stem cells, particularly those resident in tissues with little turnover, are largely quiescent and only activate in response to regenerative demands, while embryonic stem cells continuously replicate, suggesting profoundly different regulatory mechanisms within distinct stem cell types. In recent years, evidence linking metabolism, mitochondrial dynamics, and protein homeostasis (proteostasis) as fundamental regulators of stem cell function has emerged. Here, we discuss new insights into how these networks control potency, self-renewal, differentiation, and aging of highly proliferative embryonic stem cells and quiescent adult stem cells, with a focus on hematopoietic and muscle stem cells and implications for anti-aging research.
• dc.description.sponsorship We thank Dr. E. Perdiguero for design and advice in artwork. P.M.-C. is supported by MINECO (SAF2015-67369-R, María de Maeztu Program for Units of Excellence to UPF [MDM-2014-0370], Severo Ochoa Program for Centers of Excellence to CNIC [SEV-2015-0505]), Convenio UPF-CNIC, ERC-741538, AFM, E-Rare/Eranet, MDA, Fundació Marató-TV3, and DPPE. P.S.-V. is supported by the Glenn Foundation for Medical Research. The authors apologize for work not being mentioned owing to space restrictions.
• dc.format.mimetype application/pdf
• dc.identifier.citation García-Prat L, Sousa-Victor P, Muñoz-Cánoves P. Proteostatic and metabolic control of stemness. Cell Stem Cell. 2017 May 4;20(5):593-608. DOI: 10.1016/j.stem.2017.04.011
• dc.identifier.doi http://dx.doi.org/10.1016/j.stem.2017.04.011
• dc.identifier.issn 1934-5909
• dc.identifier.uri http://hdl.handle.net/10230/36844
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Cell Stem Cell. 2017 May 4;20(5):593-608
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/741538
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2015-67369-R
• dc.rights © Elsevier This is the published version of an article http://dx.doi.org/10.1016/j.stem.2017.04.011 that appeared in the journal Cell stem cell. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: https://www.elsevier.com/about/our-business/policies/open-access-licenses/elsevier-user-license
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://www.elsevier.com/open-access/userlicense/1.0/
• dc.subject.keyword Stem cells
• dc.subject.keyword Satellite cells
• dc.subject.keyword Hematopoietic stem cells
• dc.subject.keyword Pluripotent stem cells
• dc.subject.keyword Quiescence autophagy
• dc.subject.keyword Proteostasis
• dc.subject.keyword Metabolism
• dc.subject.keyword Mitochondria
• dc.subject.keyword Aging
• dc.title Proteostatic and metabolic control of stemness
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion