International stroke genetics consortium recommendations for studies of genetics of stroke outcome and recovery
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- dc.contributor.author Lindgren, Arne G.
- dc.contributor.author Jiménez Conde, Jordi
- dc.contributor.author Fernández-Cadenas, Israel
- dc.contributor.author International Stroke Genetics Consortium
- dc.date.accessioned 2022-06-16T06:19:08Z
- dc.date.available 2022-06-16T06:19:08Z
- dc.date.issued 2022
- dc.description.abstract Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery. However, this usually requires combining data from multiple studies where consistent terminology, methodology, and data collection timelines are essential. Our group of expert stroke and rehabilitation clinicians and researchers with knowledge in genetics of stroke recovery here present recommendations for harmonizing phenotype data with focus on measures suitable for multicenter genetic studies of ischemic stroke brain injury and recovery. Our recommendations have been endorsed by the International Stroke Genetics Consortium.
- dc.format.mimetype application/pdf
- dc.identifier.citation Lindgren AG, Braun RG, Juhl Majersik J, Clatworthy P, Mainali S, Derdeyn CP, et al. International stroke genetics consortium recommendations for studies of genetics of stroke outcome and recovery. Int J Stroke. 2022 Mar;17(3):260-8. DOI: 10.1177/17474930211007288
- dc.identifier.doi http://dx.doi.org/10.1177/17474930211007288
- dc.identifier.issn 1747-4930
- dc.identifier.uri http://hdl.handle.net/10230/53508
- dc.language.iso eng
- dc.publisher SAGE Publications
- dc.rights Copyright © 2021 World Stroke Organization. This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Data collection
- dc.subject.keyword Genetics
- dc.subject.keyword Ischemic stroke
- dc.subject.keyword Outcome
- dc.subject.keyword Phenotype
- dc.subject.keyword Recovery
- dc.subject.keyword Standardization
- dc.title International stroke genetics consortium recommendations for studies of genetics of stroke outcome and recovery
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion