From chromatin to splicing: RNA-processing as a total artwork
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- dc.contributor.author Tilgner, Hagen, 1980-ca
- dc.contributor.author Guigó Serra, Rodericca
- dc.date.accessioned 2016-01-12T13:32:06Z
- dc.date.available 2016-01-12T13:32:06Z
- dc.date.issued 2010
- dc.description.abstract RNA plays a central role in the determination of the phenotype of the cell. The molecular mechanisms involved in primary RNA synthesis and subsequent post-processing are not completely understood, but there is increasing evidence that they are more tightly coupled than previously expected. The analyses by a number of groups of recently published genome wide maps of chromatin structure have further uncovered a role for primary chromatin structure in RNA processing. Indeed, these analyses have revealed that nucleosomes show a characteristic occupancy pattern in exonic regions of metazoan genomes. The pattern is strongly indicative of an implication of nucleosome positioning in exon recognition during pre-mRNA splicing. Characteristic exonic patterns have also been observed for a number of histone modifications, suggesting the possibility that chromatin state plays a direct role in the regulation of splicingca
- dc.format.mimetype application/pdfca
- dc.identifier.citation Tilgner H, Guigó R. From chromatin to splicing: RNA-processing as a total artwork. Epigenetics. 2010; 5(3): 180-184. DOI 10.4161/epi.5.3.11319ca
- dc.identifier.doi http://dx.doi.org/10.4161/epi.5.3.11319
- dc.identifier.issn 1559-2294
- dc.identifier.uri http://hdl.handle.net/10230/25556
- dc.language.iso engca
- dc.publisher Taylor & Francis (Routledge)ca
- dc.relation.ispartof Epigenetics. 2010; 5(3): 180-184
- dc.rights © 2010 Landes Bioscience. This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri https://creativecommons.org/licenses/by-nc/3.0/ca
- dc.subject.keyword Splicing
- dc.subject.keyword Transcription
- dc.subject.keyword Chromatin
- dc.subject.keyword Epigenetics
- dc.subject.keyword Nucleosome positioning
- dc.subject.keyword Bioinformatics
- dc.subject.other Cromatinaca
- dc.subject.other RNA missatgerca
- dc.subject.other Exonsca
- dc.title From chromatin to splicing: RNA-processing as a total artworkca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca