Synthetic criticality in cellular brains

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• dc.contributor.author Solé, Ricard
• dc.contributor.author Conde Pueyo, Núria, 1983-
• dc.contributor.author Guillamon i Grabolosa, Antoni
• dc.contributor.author Maull, Victor
• dc.contributor.author Pla, Jordi
• dc.contributor.author Sardanyés i Cayuela, Josep
• dc.contributor.author Vidiella Rocamora, Blai
• dc.date.accessioned 2022-03-18T10:52:54Z
• dc.date.available 2022-03-18T10:52:54Z
• dc.date.issued 2021
• dc.description.abstract Cognitive networks have evolved to cope with uncertain environments in order to make reliable decisions. Such decision making circuits need to respond to the external world in efficient and flexible ways, and one potentially general mechanism of achieving this is grounded in critical states. Mounting evidence has shown that brains operate close to such critical boundaries consistent with self-organized criticality (SOC). Is this also taking place in small-scale living systems, such as cells? Here, we explore a recent model of engineered gene networks that have been shown to exploit the feedback between order and control parameters (as defined by expression levels of two coupled genes) to achieve an SOC state. We suggest that such SOC motif could be exploited to generate adaptive behavioral patterns and might help design fast responses in synthetic cellular and multicellular organisms.en
• dc.description.sponsorship This work was supported by the Spanish Ministry of Economy and Competitiveness, Grant PID2019-111680GB-I00, an MICIN Grant PID2019-111680GB-I00 and an AGAUR FI 2018 Grant. JS has been partially funded by the CERCA Programme of the 'Generalitat de Catalunya', by 'Agencia Estatal de Investigación' Grant RTI2018-098322-B-I00 and by the 'Ramón y Cajal' contract RYC-2017-22243. AG has been funded by the AGAUR Grant 2017-SGR-1049 and by the MINECO-FEDER-UE Grants PGC-2018-098676-B-100 and RTI2018-093860-B-C21. JP was funded by FPI 2020en
• dc.format.mimetype application/pdf
• dc.identifier.citation Solé R, Conde-Pueyo N, Guillamon A, Maull V, Pla J, Sardanyés J et al. Synthetic criticality in cellular brains. Journal of physics. Complexity. 2021;2(4):041001. DOI:10.1088/2632-072X/ac35b3
• dc.identifier.doi http://doi.org/10.1088/2632-072X/ac35b3
• dc.identifier.issn 2632-072X
• dc.identifier.uri http://hdl.handle.net/10230/52716
• dc.language.iso eng
• dc.publisher IOPscience
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RYC-2017-22243
• dc.rights © Ricard Solé et al. 2021. Published by IOP Publishing Ltd. Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.other Genèticaca
• dc.subject.other Cervellca
• dc.title Synthetic criticality in cellular brainsen
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion