Comorbidity between Alzheimer's disease and major depression: a behavioural and transcriptomic characterization study in mice

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  • dc.contributor.author Martín Sánchez, Ana
  • dc.contributor.author Piñero González, Janet, 1977-
  • dc.contributor.author Nonell Mazelon, Lara, 1972-
  • dc.contributor.author Arnal, Magdalena
  • dc.contributor.author Ribe, Elena
  • dc.contributor.author Nevado-Holgado, Alejo J.
  • dc.contributor.author Lovestone, Simon
  • dc.contributor.author Sanz, Ferran
  • dc.contributor.author Furlong, Laura I., 1971-
  • dc.contributor.author Valverde, Olga
  • dc.date.accessioned 2021-05-07T07:06:04Z
  • dc.date.available 2021-05-07T07:06:04Z
  • dc.date.issued 2021
  • dc.description.abstract Background: Major depression (MD) is the most prevalent psychiatric disease in the population and is considered a prodromal stage of the Alzheimer's disease (AD). Despite both diseases having a robust genetic component, the common transcriptomic signature remains unknown. Methods: We investigated the cognitive and emotional behavioural responses in 3- and 6-month-old APP/PSEN1-Tg mice, before β-amyloid plaques were detected. We studied the genetic and pathway deregulation in the prefrontal cortex, striatum, hippocampus and amygdala of mice at both ages, using transcriptomic and functional data analysis. Results: We found that depressive-like and anxiety-like behaviours, as well as memory impairments, are already present at 3-month-old APP/PSEN1-Tg mutant mice together with the deregulation of several genes, such as Ciart, Grin3b, Nr1d1 and Mc4r, and other genes including components of the circadian rhythms, electron transport chain and neurotransmission in all brain areas. Extending these results to human data performing GSEA analysis using DisGeNET database, it provides translational support for common deregulated gene sets related to MD and AD. Conclusions: The present study sheds light on the shared genetic bases between MD and AD, based on a comprehensive characterization from the behavioural to transcriptomic level. These findings suggest that late MD could be an early manifestation of AD.
  • dc.description.sponsorship This study was funded by the EU Medbioinformatic project (grant number 634143), Ministerio de Economia y Competitividad (grant number SAF2016-75966-R-FEDER and PID2019-104077-RB-100) and Ministerio de Sanidad (Retic-ISCIII, RD16/017/010 and Plan Nacional sobre Drogas 2018/007). The Department of Experimental and Health Sciences (UPF) is a “Unidad de Excelencia María de Maeztu” funded by the AEI (CEX2018-000792-M). The Research Programme on Biomedical Informatics (GRIB) is a member of the Spanish National Bioinformatics Institute (INB), funded by ISCIII and FEDER (PT17/0009/0014). The GRIB is also supported by the Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR), Generalitat de Catalunya (2017 SGR 00519).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Martín-Sánchez A, Piñero J, Nonell L, Arnal M, Ribe EM, Nevado-Holgado A, Lovestone S, Sanz F, Furlong LI, Valverde O. Comorbidity between Alzheimer's disease and major depression: a behavioural and transcriptomic characterization study in mice. Alzheimers Res Ther. 2021; 13(1):73. DOI: 10.1186/s13195-021-00810-x
  • dc.identifier.doi http://dx.doi.org/10.1186/s13195-021-00810-x
  • dc.identifier.issn 1758-9193
  • dc.identifier.uri http://hdl.handle.net/10230/47344
  • dc.language.iso eng
  • dc.publisher BioMed Central
  • dc.relation.ispartof Alzheimers Res Ther. 2021; 13(1):73
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/634143
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2016-75966-R
  • dc.rights © The Author(s). 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Alzheimer’s disease
  • dc.subject.keyword Behaviour
  • dc.subject.keyword Comorbidity
  • dc.subject.keyword Gene Set Enrichment Analysis
  • dc.subject.keyword Major depression
  • dc.subject.keyword Transcriptome
  • dc.title Comorbidity between Alzheimer's disease and major depression: a behavioural and transcriptomic characterization study in mice
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion